1. Epigenetics
  2. Histone Methyltransferase
  3. Pociredir

Pociredir (Synonyms: FTX-6058)

Cat. No.: HY-139400B
Handling Instructions

Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD).

For research use only. We do not sell to patients.

Pociredir Chemical Structure

Pociredir Chemical Structure

CAS No. : 2490674-02-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Pociredir:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with KD value of 0.163 nM. Pociredir can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD)[1][2].

In Vivo

Pociredir (QD, 5 mg/kg) reduces the H3K27me3 levels in the Townes mouse model of sickle cell disease (SCD)[1].
Pociredir (QD, 5 mg/kg) increases the levels of red blood cells and total hemoglobin, ameliorates hemolysis in the Townes mouse model of sickle cell disease (SCD)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

403.41

Formula

C22H18FN5O2

CAS No.
SMILES

FC1=C2C3=C(C=C1)OC[[email protected]]3([H])COC4=C(N5C(C(C6=C(N=CC=C6)C)=C4)=NN=C5)NC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pociredir
Cat. No.:
HY-139400B
Quantity:
MCE Japan Authorized Agent: