2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. DB-959

DB-959 (PPARδ/γ agonist 1) is a potent dual PPAR delta/gamma inhibitor. DB-959 can be used for Alzheimer’s disease research.

For research use only. We do not sell to patients.

DB-959 Chemical Structure

DB-959 Chemical Structure

CAS No. : 1257641-15-8

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Description

DB-959 (PPARδ/γ agonist 1) is a potent dual PPAR delta/gamma inhibitor. DB-959 can be used for Alzheimer’s disease research[1].

In Vivo

PPARδ/γ agonist 1 (1 mg/kg; i.g.; daily, for 16 days; STZ-mediated Long Evans rats) restores STZ-mediated impairments of motor function[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ-mediated Long Evans rats[1]
Dosage: 1 mg/kg
Administration: Oral gavage; daily, for 16 days
Result: Improved performance in the STZ-mediated rats and had neuroprotective for both granule and Purkinje cells.
Molecular Weight

421.49

Formula

C25H27NO5
CAS No.
SMILES

O=C(O)C[C@@H]1CCC2=C1C=CC(OCCC3=C(CC)OC(C4=CC=C(OC)C=C4)=N3)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DB-959 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DB-9591257641-15-8PPARδ/γ agonist 1DB959DB 959PPARPeroxisome proliferator-activated receptorsneuroprotectivegranule cellsPurkinje cellsAlzheimer’s diseaseInhibitorinhibitorinhibit

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