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PQ-912 

Cat. No.: HY-123821
Handling Instructions

PQ-912 is a competitive inhibitor of the enzyme glutaminyl cyclase. PQ-912 inhibits human, rat, and mouse glutaminyl cyclase activity, with Ki values ranging between 20 and 65 nM.

For research use only. We do not sell to patients.

PQ-912 Chemical Structure

PQ-912 Chemical Structure

CAS No. : 1276021-65-8

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Description

PQ-912 is a competitive inhibitor of the enzyme glutaminyl cyclase[1]. PQ-912 inhibits human, rat, and mouse glutaminyl cyclase activity, with Ki values ranging between 20 and 65 nM[2].

IC50 & Target

Ki: 25 nM (human glutaminyl cyclase, pH:8.0); 65 nM (Mouse glutaminyl cyclase; pH:8.0)[2]

In Vivo

PQ-912 (oral treatment; 200 mg/kg/day for 1 week in hAPPSLxhQC double-transgenic mice) shows a significant reduction of pE-Aβ levels[2].

Animal Model: hAPPSLxhQC double-transgenic mice[2]
Dosage: 200 mg/kg
Administration: Oral treatment; daily for 1 week
Result: Showed a significant reduction of pE-Aβ levels.
References
Molecular Weight

336.39

Formula

C₁₉H₂₀N₄O₂

CAS No.

1276021-65-8

SMILES

O=C1NC[[email protected]](C2=CC=C(OCCC)C=C2)N1C3=CC=C4N=CNC4=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PQ-912
Cat. No.:
HY-123821
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PQ-912

Cat. No.: HY-123821