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  3. PQ-912

PQ-912 

Cat. No.: HY-123821 Purity: 99.59% ee.: 98.70%
Handling Instructions

PQ-912 is a competitive inhibitor of the enzyme glutaminyl cyclase (QC). PQ-912 inhibits human, rat, and mouse glutaminyl cyclase activity, with Ki values ranging between 20 and 65 nM.

For research use only. We do not sell to patients.

PQ-912 Chemical Structure

PQ-912 Chemical Structure

CAS No. : 1276021-65-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PQ-912 is a competitive inhibitor of the enzyme glutaminyl cyclase (QC)[1]. PQ-912 inhibits human, rat, and mouse glutaminyl cyclase activity, with Ki values ranging between 20 and 65 nM[2].

IC50 & Target

Ki: 25 nM (human glutaminyl cyclase, pH:8.0); 65 nM (Mouse glutaminyl cyclase; pH:8.0)[2]

In Vivo

PQ-912 (oral treatment; 200 mg/kg/day for 1 week in hAPPSLxhQC double-transgenic mice) shows a significant reduction of pE-Aβ levels[2].

Animal Model: hAPPSLxhQC double-transgenic mice[2]
Dosage: 200 mg/kg
Administration: Oral treatment; daily for 1 week
Result: Showed a significant reduction of pE-Aβ levels.
Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (594.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

336.39

Formula

C₁₉H₂₀N₄O₂

CAS No.

1276021-65-8

SMILES

O=C1NC[[email protected]](C2=CC=C(OCCC)C=C2)N1C3=CC=C4N=CNC4=C3

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PQ-912
Cat. No.:
HY-123821
Quantity:

PQ-912

Cat. No.: HY-123821