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PRGL493 

Cat. No.: HY-139180 Purity: 99.12%
Handling Instructions

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research.

For research use only. We do not sell to patients.

PRGL493 Chemical Structure

PRGL493 Chemical Structure

CAS No. : 2479378-45-3

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5 mg USD 180 Ask For Quote & Lead Time
10 mg USD 290 Ask For Quote & Lead Time

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Description

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research[1].

IC50 & Target

IC50: ACSL4[1]

In Vitro

Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-A family taking part in arachidonic acid metabolism and steroidogenesis[1].
PRGL493 ([3H]-AA (0.5 µCi/ml in serumfree medium) for 3 h; 48 hours) signifcantly inhibits the activity of ACSL4 in all three cell lines (MDA-MB-231, PC-3 and MA-10 Leydig cells), as evidenced by a reduction in AA-CoA levels.But PRGL493 has no effects on ACSL4 protein expression[1].
PRGL493 (20-100 μM; 72 hours) inhibits the proliferation of highly aggressive breast and prostate cancer cells at an IC50 of 23 µM and 27 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PRGL493 (intraperitoneal injection; 250 μg/Kg; 43 and 34 consecutive days) decreases tumor volumes and inhibits tumor growth. Additionally, this compound results in a decrease in Ki67 protein expression and increases ER and AR expression in breast and prostate xenograft tumors, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231 or PC-3 cell suspensions mixed with Matrigel Matrix in a 3/1 dilution are injected into the right fank of NLAE:NIH(S)Fox1nu mice, aged 7-8 weeks[1]
Dosage: 250 μg/kg
Administration: Intraperitoneal injection; 250 μg/kg; 43 and 34 consecutive days
Result: Inhibited tumor growth in vivo models
Molecular Weight

451.48

Formula

C₂₅H₂₁N₇O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.07 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2149 mL 11.0747 mL 22.1494 mL
5 mM 0.4430 mL 2.2149 mL 4.4299 mL
10 mM 0.2215 mL 1.1075 mL 2.2149 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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PRGL493
Cat. No.:
HY-139180
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