2. PROTAC
    Vitamin D Related/Nuclear Receptor
    Apoptosis
  3. PROTACs
    Androgen Receptor
    Apoptosis
  4. PROTAC AR-V7 degrader-2

PROTAC AR-V7 degrader-2 

Cat. No.: HY-148771
Handling Instructions

PROTAC AR-V7 degrader-2 is an AR-based PROTAC. PROTAC AR-V7 degrader-2 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. PROTAC AR-V7 degrader-2 induces apoptosis.

For research use only. We do not sell to patients.

PROTAC AR-V7 degrader-2 Chemical Structure

PROTAC AR-V7 degrader-2 Chemical Structure

CAS No. : 2488296-74-6

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Description

PROTAC AR-V7 degrader-2 is an AR-based PROTAC. PROTAC AR-V7 degrader-2 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. PROTAC AR-V7 degrader-2 induces apoptosis[1].

In Vitro

PROTAC AR-V7 degrader-2 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner[1].
PROTAC AR-V7 degrader-2 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels[1].
PROTAC AR-V7 degrader-2 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 22Rvl cells
Concentration: 0-20 μM
Incubation Time: 4 days
Result: Reduced the cell count by less than 50 percent.

Apoptosis Analysis[1]

Cell Line: 22Rvl cells
Concentration: 1 μM
Incubation Time: 0-48 h
Result: Induced cell apoptosis in 22Rvl cells.

Western Blot Analysis[1]

Cell Line: 22Rvl cells
Concentration: 10 μM
Incubation Time: 4 days
Result: Reduced AR-V7 protein levels.
In Vivo

PROTAC AR-V7 degrader-2 (compound 16; 2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-EnzR tumor xenografts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nu/nu mice with 22Rvl-EnzR tumor xenografts[1]
Dosage: 2.5 mg/mL
Administration: intratumor injection
Result: Inhibited tumor growth in nu/nu mice with 22Rvl-EnzR tumor xenografts.
Molecular Weight

882.05

Formula

C43H53F2N7O7S2
CAS No.
SMILES

O=C(N1[[email protected]@H](C[[email protected]](C1)O)C(N[[email protected]](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[[email protected]](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC AR-V7 degrader-22488296-74-6PROTACsAndrogen ReceptorApoptosisPROTACAR-V7AR-FLCaP cellularInhibitorinhibitorinhibit

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