1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. 4-1BB (CD137) & 4-1BBL

4-1BB (CD137; TNFRSF9), a TNF receptor superfamily (TNFRSF) member, is an inducible co-stimulatory receptor primarily expressed on the surface of activated lymphoid cells, including T cells, B cells, and NK cells. 4-1BB plays an important role in expansion, acquisition of effector function, survival, and development of T cell memory. 4-1BB ligand, 4-1BBL, is expressed as a type II transmembrane protein primarily on antigen-presenting cells, such as dendritic cells (DC), macrophages, and B cells. Once expressed, 4-1BB binds 4-1BBL and recruits intracellular TNFR-associated factor (TRAF1 and TRAF2) to activate the NF-kB, AKT, p38 MAPK, and ERK pathways. The signaling pathways trigger to subsequent immune cell proliferation and activation, particularly of T and NK cells. Growing evidence indicates that targeting 4-1BB or 4-1BBL has important implications in many clinical conditions, including cancer.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity