1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. C chemokine subfamily

The C chemokine subfamily (or γ chemokines) lacks the first and third cysteines and thus possesses only a single cysteine residue in the conserved position. This subfamily is composed of two members, XCL1 (also known as lymphotactin, Ltn, ATAC, SCYC-1, or SCM1-α), and XCL2 (SCM1-β, SCYC-2). XCL1 and XCL2 are produced by activated NK cells, CD8 T cells, γδ T cell and NKT cells. Structurally, XCL1 and XCL2 are very similar, exchanging between the monomeric chemokine fold and an unrelated dimeric state under physiological NaCl and temperature conditions. Binding of the XCL1 and XCL2 to the XCR1 receptor is considered to fix the conformation of XCR1 in an active state, which facilitates the receptor to interact with and activate heterotrimeric G proteins through the GDP/GTP exchange. This results in the dissociation of the G alpha subunit and the G beta-gamma subunits, leading to activation of downstream signaling pathways. XCL1 and XCL2 engagement of XCR1 triggers a variety of cellular responses including intracellular Ca 2+ flux and chemotaxis/chemokinesis.

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