1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. CD200 & CD200R

CD200 (OX2), an co-stimulatory immune checkpoint protein, is a cell surface type I glycoprotein in that belongs to the Immunoglobulin superfamily , and is expressed by a variety of cells, including B cells, activated T cells, follicular dendritic cells (DCs), and neurons. CD200 exerts its effect by binding to a structurally similar CD200 receptor (CD200R1 to CD200R4), triggering intracellular signaling cascades. CD200R (OX2R) is highly expressed on macrophages, neutrophils, monocytes, mast cells, and lymphocytes, and expression has also been localized on microglia. The CD200 receptor-ligand system can regulate the activation threshold of inflammatory immune responses, polarize cytokine production, and maintain immune homeostasis. Neurons can enhance neuroprotection by the CD200-CD200R pathway. Importantly, CD200 is expressed in a wide spectrum of cancers, including chronic lymphocytic leukemia (CLL), multiple myeloma, acute myeloid leukemia, melanoma, ovarian tumors, metastatic small cell carcinoma, and glioblastoma. Full-length CD200 secreted from tumor cells binds to the CD200 inhibitory receptor (CD200R1) on antigen-presenting cells, shutting down an immune response.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity