1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. CD226 (DNAM-1) & CD155/CD112

CD226 (DNAM-1) & CD155/CD112

DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating/co-stimulatory receptor of the immunoglobulin superfamily (IgSF). DNAM-1 is a 65-kD immunoglobulin-like transmembrane glycoprotein consisting of an extracellular region with two IgV-like domains, a transmembrane region, a cytoplasmic region with an Ig tail-tyrosine (ITT), and four putative tyrosine residues and one serine residue that are phosphorylated. DNAM-1 is mainly expressed on the majority of monocytes, T cells, Natural killer (NK) cells and platelets and on small subsets of B cells. DNAM-1 promotes intercellular adhesion, lymphocyte signaling, and lymphokine secretion and enhances NK cell and cytotoxic T cell (CTL) cytotoxicity. Ligands for CD226 include CD155 (necl-5; PVR) and CD112 (nectin-2; PVRL2). They are normally expressed on epithelial, endothelial, and antigen-presenting cells (APCs) and are highly up-regulated on tumor cells.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity