1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. CD27 & CD70

Cluster of differentiation 27 (CD27, also TNFRSF7), a co-stimulatory receptor, is a transmembrane phosphoglycoprotein which is expressed on naive T-cells, memory B-cells, natural killer (NK) -cells, and hematopoietic stem cells (HSCs) and progenitor cell. CD27 is expressed on both CD4+ and CD8+ T-cells with increased expression upon T-cell activation and shedding from the cellular surface and formation of soluble CD27 (sCD27) upon activation. CD27 belongs to the tumour necrosis factor receptor superfamily (TNFRSF), binds to its natural ligand CD70 (CD27 ligand or CD27-L), a member of the TNF family, which is quite restrictively and only transiently expressed on activated immune cells, including T cells, B cells, dendritic cells (DCs) and NK cells. CD27 interaction with its ligand CD70 results in intracellular signaling which potentiates survival and activation of T, B, and NK cells via Traf2 and Traf5 signaling and activation of the NF-κB pathway. Therefore, CD27/CD70 co-stimulation has the potential to boost the immunity by T-cell activation, increased clonal expansion and enhanced differentiation into antigen-specific cytotoxic and memory T cells.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity