1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. CD28 & CD80/CD86

CD28 is a stimulatory cell surface receptor of the immunoglobulin (Ig) superfamily. It is expressed on virtually all T-cells in rodents, and on the vast majority of CD4+ but only about half of circulating human CD8+ T-cells. The ligands for CD28 are CD80 (B7/BB1 or B7-1) and CD86 (B7-2), are also members of the Ig superfamily. The binding of CD28 receptors and ligands causes epigenetic, transcriptional and post-translational alterations in T cells. Specifically, CD28 co-stimulation controls many aspects within T cells, one being the expression of pro-inflammatory cytokine, such as IL-2. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis. Thus, the CD28 co-stimulatory receptor represents a promising target for immunosuppressive drugs. CD28 is the founding member of a subfamily of co-stimulatory molecules characterized by an extracellular variable immunoglobulin-like domain. Other members of the subfamily include ICOS, CTLA4, PD1, and BTLA. Among them, CD28 and CTLA4 are highly homologous and compete for the same ligands (CD80 and CD86).

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity