1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. CD48 (SLAMF2) & CD2/CD244

CD48 (SLAMF2) & CD2/CD244

Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48, BLAST-1) is an adhesion and co-stimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen presenting cells (APC). It is up-regulated on subsets of activated cells. CD48 belongs to the CD2 subfamily of the immunoglobulin (Ig) superfamily. CD48 has multiple binding partners with diverse immunologic functions. CD48 contributes to several immunological processes by binding to the immunoreceptors CD2 and SLAMF4 (CD244/2B4). Besides, CD48 can bind to the lectin FimH on E. coli, facilitating detection and endocytosis of bacteria by macrophages and mast cells. In brief, CD48 is involved in cell adhesion and co-stimulation, regulation of target cell lysis by cytolytic cells, as well as detection of microbes through its interaction with the bacterial component FimH. CD48 expression is increased in autoimmunity and allergy diseases, and it is reported that anti-CD48 monoclonal antibodies can attenuate experimental autoimmune encephalomyelitis.

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