1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CXC chemokine subfamily

CXC chemokine subfamily

The CXC subfamily (or α-chemokines), a pleiotropic family of cytokines, is characterized by four highly conserved cysteine amino acid residues, with two cysteine residues (C) and a non-cysteine amino acid (X) between them. The CXC family is known for its ability to promote trafficking of various leukocytes and to regulate angiogenesis and vascular remodelling. Depending on the presence or absence of the ELR motif (the sequence Glu-Leu-Arg), which immediately precedes the first cysteine residue near the amino-terminal end, CXC chemokines are potent promoters or inhibitors of angiogenesis. The ELR-positive chemokines (i.e., CXCL1 to CXCL3 and CXCL5 to CXCL8) are angiogenic and act mainly through the CXCR2 receptor. The ELR motif, along with the CXC residues, is required for receptor activation. By contrast, the non-ELR chemokines (CXCL4, CXCL9, CXCL10, CXCL11 and CXCL17) are angiostatic and act mainly through the CXCR3B receptor. The exception to this is CXCL12, which is a non-ELR chemokine but is angiogenic and exerts its effects on the vasculature primarily by binding to CXCR4 and CXCR7. (Targeting CXCR )

Cat. No. Product Name / Synonyms Species Source
  • HY-P7228
    I-TAC/CXCL11 Protein, Human (HEK293)

    rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11

    Human HEK293
    I-TAC/CXCL11 Protein, Human (HEK293) is a small cytokine belonging to the CXC chemokine family which can be strongly induced by IFN-gamma, and its receptor CXCR3.
  • HY-P7268
    NAP-2/CXCL7 Protein, Human

    rHuNAP-2/CXCL7; C-X-C motif chemokine 7; Platelet basic protein; MDGF; SCYB7

    Human E. coli
    NAP-2/CXCL7 Protein, Human is one of the CXC chemokine subfamily members, and is well known as a functional activator of neutrophils.
  • HY-P7227
    IP-10/CXCL10 Protein, Mouse

    rMuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1

    Mouse E. coli
    IP-10/CXCL10 Protein, Mouse is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties.
  • HY-P7131
    BCA-1/CXCL13 Protein, Human

    rHuBCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13

    Human E. coli
    BCA-1/CXCL13 Protein, Human is identified as an efficacious and selective attractant for B lymphocytes, also acts as a B cell homing chemokine.
  • HY-P70508
    GRO-alpha/CXCL1 Protein, Human (HEK 293, His)

    Growth-Regulated Alpha Protein; C-X-C Motif Chemokine 1; GRO-Alpha(1-73); Melanoma Growth Stimulatory Activity; MGSA; Neutrophil-Activating Protein 3; NAP-3; CXCL1; GRO; GRO1; GROA; MGSA; SCYB1

    Human HEK293
  • HY-P7284
    SDF-1 alpha/CXCL12 Protein, Human (68a.a)

    rHuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF

    Human E. coli
    SDF-1 alpha/CXCL12 Protein, Human (68a.a) is a member of CXC chemokine family, binds to CXCR4 and CXCR7, and is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression.
  • HY-P7379
    IL-8/CXCL8 Protein, Human (CHO)

    rHuIL-8/CXCL8; C-X-C motif chemokine 8; NAP-1; IL8; GCP-1

    Human CHO
    IL-8/CXCL8 Protein, Human (CHO) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation.
  • HY-P7258
    MIP-2/CXCL2 Protein, Mouse

    rMuMIP-2/CXCL2; C-X-C motif chemokine 2; SCYB2

    Mouse E. coli
    MIP-2/CXCL2 Protein, Mouse is a member of the CXC chemokine family, and can recruit neutrophils to infection sites.
  • HY-P7285
    SDF-1 alpha/CXCL12 Protein, Mouse

    rMuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF

    Mouse E. coli
    SDF-1 alpha/CXCL12 Protein, Mouse is a member of CXC chemokine family, binds to CXCR4 and CXCR7, and is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression.
  • HY-P7188
    GRO-alpha/CXCL1 Protein, Mouse

    rMuGRO-α/CXCL1; Growth-regulated alpha protein; C-X-C motif chemokine 1; KC; HSF

    Mouse E. coli
    GRO-alpha/CXCL1 Protein, Mouse could play a major role in inflammation, angiogenesis, tumorigenesis, and wound healing.
  • HY-P70469
    SDF-1 alpha/CXCL12 Protein, Human

    Stromal Cell-Derived Factor 1; SDF-1; hSDF-1; C-X-C Motif Chemokine 12; Intercrine Reduced in Hepatomas; IRH; hIRH; Pre-B Cell Growth-Stimulating Factor; PBSF; CXCL12; SDF1; SDF1A; SDF1B

    Human E. coli
  • HY-P7224
    IL-8/CXCL8 Protein, Human (77a.a)

    rHuIL-8/CXCL8; C-X-C motif chemokine 8; Emoctakin; MDNCF; NAP-1; IL8

    Human E. coli
    IL-8/CXCL8 Protein, Human (77a.a) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation.
  • HY-P7226
    IP-10/CXCL10 Protein, Human

    rHuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1

    Human E. coli
    IP-10/CXCL10 Protein, Human is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties.
  • HY-P7158
    ENA-78/CXCL5 Protein, Human

    rHuENA-78/CXCL5; ENA78; SCYB5

    Human E. coli
    ENA-78/CXCL5 Protein, Human, a CXC chemokine, is a promoter of cell proliferation, migration and invasion.
  • HY-P7287
    SDF-1 beta/CXCL12 Protein, Human (72a.a)

    rHuSDF-1β/CXCL12; C-X-C motif chemokine 12; PBSF

    Human E. coli
    SDF-1 beta/CXCL12 Protein, Human (72a.a) is a member of CXC chemokine family, binds to CXCR4 and CXCR7, and is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression.
  • HY-P70008
    MIG/CXCL9 Protein, Mouse (HEK293, His)

    rMuC-X-C motif chemokine 9/CXCL9, His; C-X-C motif chemokine 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; MIG; MuMIG; Protein m119; Small-inducible cytokine B9; Cxcl9; Mig; Scyb9

    Mouse HEK 293
  • HY-P7157
    ENA-78/CXCL5 Protein, Human (HEK293)

    rHuENA-78/CXCL5; ENA78; SCYB5

    Human HEK293
    ENA-78/CXCL5 Protein, Human (HEK293), a CXC chemokine, is a promoter of cell proliferation, migration and invasion.
  • HY-P7383
    LIX/CXCL5 Protein, Mouse (74a.a, CHO)

    rMuLIX/CXCL5, 74a.a.; LIX; C-X-C motif chemokine 5; SCYB5

    Mouse CHO
    LIX/CXCL5 Protein, Mouse (74a.a, CHO) is a promoter of cell proliferation, migration and invasion.
  • HY-P7187
    GRO-alpha/CXCL1 Protein, Human

    rHuGRO-α/CXCL1; NAP-3; MGSA; Growth-regulated alpha protein

    Human E. coli
    GRO-alpha/CXCL1 Protein, Human could play a major role in inflammation, angiogenesis, tumorigenesis, and wound healing.
  • HY-P7229
    I-TAC/CXCL11 Protein, Human

    rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11

    Human E. coli
    I-TAC/CXCL11 Protein, Human is a small cytokine belonging to the CXC chemokine family which can be strongly induced by IFN-gamma, and its receptor CXCR3.
Cat. No. Product Name Effect Purity