1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF superfamily
  4. ERBB2

The receptor tyrosine-protein kinase ErbB2 (HER2/neu) is a member of the epidermal growth factor receptor (EGFR) family, which also includes EGFR (ErbB1), ErbB3 (HER3), and ErbB4 (HER4). ErbB2 has no ligand-binding domain of its own, and no direct ligand for it has ever been identified, yet ERBB2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. It appears that ErbB2 is the preferred partner of all ErbB proteins. If all receptors are present then ErbB3 and ErbB4 will preferentially bind ErbB2, however, if ErbB2 is not present, only then will the two receptors interact with ErbB1. Amplification or overexpression of ErbB2 gene occurs in numerous cancers, including breast, gastric, and ovarian tumors.

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