1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear receptor superfamily
  4. Estrogen related receptors

Estrogen related receptors

Estrogen receptor-related receptors (ERRs), also called NR3B subfamily, are members of the nuclear receptor superfamily, including ERRα (ESRRA/NR3B1), ERRβ (ESRRB/NR3B2), and ERRγ (ESRRG/NR3B3). ERRs share a high degree of homology with estrogen receptors (ERs) but cannot bind to endogenous estrogen or its derivatives, and are still considered “orphan” nuclear receptor. The molecular structure of ERRs is similar to that of other nuclear receptors, and these proteins consist of six conserved regions: A/B domain containing the N-terminal domain (NTD), C domain with a DNA binding domain (DBD), D domain, which corresponds to the hinge region, E domain containing a putative LBD, and the F domain or C-terminal region. It is reported that ERRs play crucial roles in controlling the balance of cellular metabolism, general metabolism, growth and development, cancer occurrence, and bone homeostasis.