1. Recombinant Proteins
  2. Fc Receptor Proteins
  3. Fc Receptor binding IgA/IgA & IgM

Fc Receptor binding IgA/IgA & IgM

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces with an important role in host-pathogen defense. The FcαRI/CD89 is the most prominent receptor for IgA that it binds to all forms of IgA. FcαRI are expressed on neutrophils, eosinophils, monocytes/macrophages, dendritic cells, and Kupffer cells. Immunoglobulin (Ig) M is the first antibody isotype to appear during evolution, ontogeny and immune responses. IgM plays an important role in innate and adaptive immunities. Three Fc receptors for IgM have been reported, including Fcα/μ receptor (Fcα/μR), polymeric immunoglobulin receptor (pIgR), and Fcμ receptor (FcμR). Fcα/μR, pIgR, and FcμR are all type I transmembrane proteins belonging to the immunoglobulin (Ig) gene superfamily. It is noteworthy that the Fcα/μR is able to bind both IgA and IgM.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity