1. Recombinant Proteins
  2. Receptor Proteins
  3. G-Protein-Coupled Receptors
  4. Frizzled/smoothened receptors

Frizzled/smoothened receptors

G Protein-Coupled Receptors (GPCRs), also called 7TM receptors, are the largest and most important integral membrane protein families, which mediate cellular responses to most hormones, metabolites, cytokines, and neurotransmitters, and therefore serve as “fruitful targets” for drug discovery. G Protein Coupled Receptors (GPCRs) perceive many extracellular signals and transduce them to heterotrimeric G proteins, which further transduce these signals intracellular to appropriate downstream effectors and thereby play an important role in various signaling pathways. GPCRs are categorized into six classes based on sequence and function: rhodopsin-like receptors (family A), secretin-like (family B), glutamate (family C), fungal mating pheromone receptors (Class D), cAMP receptors (Class E) and frizzled/smoothened (Class F). The Class F GPCRs is evolutionarily conserved and consists of ten Frizzled (FZD1-10) paralogues and Smoothened (SMO). FZDs coordinate Wingless/Int-1(WNT) signaling and SMO mediates Hedgehog signaling. Class F receptors are intrinsically involved in embryonic development, tissue homeostasis and pathology, most prominently oncogenesis. (Targeting Smo )

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity