1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear receptor superfamily
  4. Fushi tarazu-F1 like receptors

Fushi tarazu-F1 like receptors

Fushi tarazu-F1 like receptors, as known as the NR5A- subfamily orphan nuclear receptors, includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1) in mammals and contains hormone receptor-like in 39 (Hr39) and ftz transcription factor 1 (ftz-f1) in Drosophila. All four of these proteins share 60%-90% sequence identity within their DNA binding domains and bind in vitro to identical sequences. In mammals, SF-1 and LRH-1 bind to the same DNA sequence motif, with different and nonoverlapping effects on targets. SF-1 is expressed primarily in steroidogenic tissues, while LRH-1 in tissues of endodermal origin and the gonads, and overlap of the expression of the two receptors that occurs principally in endocrine and neural tissue. Both receptors modulate cholesterol homeostasis, steroidogenesis, tissue-specific cell proliferation, and stem cell pluripotency.