1. Recombinant Proteins
  2. Receptor Proteins
  3. G-Protein-Coupled Receptors
  4. Glutamate receptors

G Protein-Coupled Receptors (GPCRs), also called 7TM receptors, are the largest and most important integral membrane protein families, which mediate cellular responses to most hormones, metabolites, cytokines, and neurotransmitters, and therefore serve as “fruitful targets” for drug discovery. G Protein Coupled Receptors (GPCRs) perceive many extracellular signals and transduce them to heterotrimeric G proteins, which further transduce these signals intracellular to appropriate downstream effectors and thereby play an important role in various signaling pathways. GPCRs are categorized into six classes based on sequence and function: rhodopsin-like receptors (family A), secretin-like (family B), glutamate (family C), fungal mating pheromone receptors (Class D), cAMP receptors (Class E) and frizzled/smoothened (Class F). Class C (glutamate) GPCRs contains 22 receptors, including the metabotropic glutamate family (mGluR1-8), gamma-aminobutyric acid (GABA) type B receptors (GABAB1 and GABAB2), calcium-sensing receptor (CaSR), taste 1 receptors (TS1R1-3), pheromone receptors, odorant receptors in fish, GPCR Class C Group 6 Member A (GPRC6A) and several orphan receptors. These receptors are characterized by a characteristically large extracellular domain and constitutive dimerization.