1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Inhibitory checkpoint molecules
  4. IRp60/CD300a

CD300a (also known as IRp60 and CMRF-35H), a type I transmembrane protein, is a non-MHC-specific inhibitory receptor belonging to CD300 family. CD300a is expressed on a variety of immune cells, including T cells, NK cells, monocytes, and granulocytes. CD300a plays a role in the regulation of immune responses, acting predominantly as an inhibitory receptor. It exhibits strong inhibitions on NK cells’ spontaneous cytotoxicity and NK-mediated cytolytic activity. Importantly, CD300a is capable of binding to tumor cells through interaction with phosphatidylserine (PS) in tumor cells, and blocking CD300A-PS interaction resulted in enhanced NK cell killing of tumor cell.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity