1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. CSF & Receptors
  4. multi-CSF/IL-3 & Receptors

multi-CSF/IL-3 & Receptors

Multi-colony-stimulating factor (multi-CSF; IL-3) is one of the hematopoietic bone marrow cell's growth factor produced primarily by the bone marrow cells and by antigen or mitogen-activated T cells. It is capable to stimulate the proliferation of early haemopoietic progenitor cells in the bone marrow. Multi-CSF signal through heterodimeric cell-surface receptors (IL-3Rs) that consist of two subunits, the α subunit specific to each and the β common chain (βc). The β subunit is common to GM-CSF, IL-3 and IL-5 receptors. Activation of the IL-3R is thought to involve sequential assembly of a receptor signaling complex whereby the critical step is the initial binding of IL-3 to IL3Rα, followed by recruitment of βc and the assembly of a high order complex which, by analogy with the GM-CSF receptor, would bring JAK2 molecules together to trigger downstream signaling. Multi-CSF is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. It has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

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