1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. OX40 & OX40L

OX40 (CD134, TNFRSF4), a type 1 transmembrane glycoprotein, is a member of the tumor necrosis factor receptor (TNFR) super family, highly expressed by activated CD4, CD8 T cells, and Tregs, and in a lesser degree by neutrophils and NK cells. OX40 is a T cell co-stimulatory molecules acting at different stages to modulate and control the immune response. The ligand of OX40 (OX40L, CD252) also belongs to the TNFR superfamily. OX40L is expressed on all activated APCs, including DCs, B cells, and macrophages, as well as on non-hematopoietic cells, including endothelial cells and smooth muscle cells. OX40, along with its ligand, OX40L, plays a pivotal role in activation, potentiation, proliferation, and survival of T cells and modulation of NK cell function. Furthermore, OX40/OX40L signaling also plays roles in Treg inhibition.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity