1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear receptor superfamily
  4. PPARs

Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that regulate gene expression. PPARs are unable to bind DNA as homodimers or monomers and function as heterodimers with their obligatory partner the retinoid X receptor (RXR). The PPAR-RXR heterodimer subsequently binds to regulatory DNA elements called peroxisome proliferator response elements (PPRE) and initiates transcription. The function of PPARs is modified by a number of co-activators and corepressors, the presence of which can either stimulate or inhibit receptor function, respectively. There are three isoforms PPARs, PPARα, PPARβ/δ, and PPARγ, which differ from each other in ligand specificity, tissue distribution, and cellular functions. PPARs are involved in the regulation of different aspects of lipid metabolism, energy production, cell differentiation, tumorigenesis, and inflammation, and have been implicated in diseases such as cancer, atherosclerosis, and diabetes. (Targeting PPAR )

Cat. No. Product Name / Synonyms Species Source
  • HY-P7999
    PPAR gamma Protein, Human (His)

    PPAR-γ-LBD

    Human E. coli
    PPAR gamma LBD Protein, Human (His) is a His-fused PPAR-gamma-LBD protein expressed by E. coli, approximately 32.6 kDa. PPAR gamma LBD Protein can be used in the ligand screening assays, western blotting, and ELISA, et al.
  • HY-P73701
    PPAR gamma Protein, Human (sf9, His-GST)

    CIMT1; GLM1; NR1C31; PPARG2; PPARG5; PPARgamma; PPARG

    Human Sf9 insect cells
Cat. No. Product Name Effect Purity