1. Recombinant Proteins
  2. Receptor Proteins
  3. Pattern Recognition Receptors
  4. RIG-I-like Receptors

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are a family of cytosolic pattern recognition receptors (PRRs) that recognize viral RNA and result in immunological response. RLRs include RIG-I (retinoic acid-inducible gene I), MDA5 (melanoma differentiation associated factor 5), and LGP2 (laboratory of genetics and physiology 2). They share a number of structural similarities including their organization into three distinct domains: 1) An N-terminal region consisting of tandem caspase activation and recruitment domains (CARD); 2) A central DExD/H box RNA helicase domain with the capacity to hydrolyze ATP and to bind RNA; 3) A repressor domain (RD) embedded within the carboxy-terminal domain (CTD). LGP2 lacks the CARDs and is widely thought to function as a regulator of RIG-I and MDA5. Upon RNA binding and oligomerization, RLRs interact with mitochondrial antiviral-signalling protein (MAVS) via CARD–CARD interactions. Activated MAVS then activates TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε), which phosphorylates IRF3 and IRF7; these, together with nuclear factor-κB (NF-κB), then induce transcription of the genes encoding type I interferons and other antiviral or immunoregulatory genes.

Cat. No. Product Name / Synonyms Species Source
  • HY-P71641
    IFIH1 Protein, Human (His)

    CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140kDa; DEAD/H (Asp Glu Ala Asp/His) box polypeptide; DEAD/H box polypeptide; Helicard; Helicase with 2 CARD domains; Hlcd; MDA-5

    Human E. coli
  • HY-P72170
    DDX58 Protein, Human (His)

    Ddx58; DDX58_HUMAN; DEAD Asp Glu Ala Asp; box polypeptide 58; DEAD Asp Glu Ala Asp/His; box polypeptide ; DEAD box protein 58; DEAD/H Asp Glu Ala Asp/His; box polypeptide RIG1; DKFZp434J1111; DKFZp686N19181; FLJ13599; Probable ATP dependent RNA helicase DDX58; Probable ATP-dependent RNA helicase DDX58; Retinoic acid inducible gene 1 protein; Retinoic acid-inducible gene 1 protein; Retinoic acid-inducible gene I protein; RIG I; Rig-1; RIG-I; RIG1; rigi; RLR 1; RNA helicase; RNA helicase RIG I; SGMRT2

    Human E. coli
Cat. No. Product Name Effect Purity