1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear receptor superfamily
  4. RORs

Retinoic acid receptor-related orphan receptor (RORs), also known as nuclear receptor subfamily 1 group F members (NR1F), are a subfamily of nuclear receptors that appear to function as ligand-dependent transcription factors. RORs include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). They exhibit a domain structure that is typical of nuclear receptors and contain an N-terminal domain, a highly conserved DNA-binding domain (DBD) consisting of two C2-C2 zinc finger motifs, a ligand-binding domain (LBD), and a hinge domain spacing the DBD and LBD. The RORs bind to ROREs as a monomer to regulate the transcription of target genes. The RORs are critical in the regulation of immunity, brain function, retinal development, glucose and lipid metabolism, and circadian rhythm.