1. Recombinant Proteins
  2. Receptor Proteins
  3. G-Protein-Coupled Receptors
  4. Secretin-like family

G Protein-Coupled Receptors (GPCRs), also called 7TM receptors, are the largest and most important integral membrane protein families, which mediate cellular responses to most hormones, metabolites, cytokines, and neurotransmitters, and therefore serve as “fruitful targets” for drug discovery. G Protein Coupled Receptors (GPCRs) perceive many extracellular signals and transduce them to heterotrimeric G proteins, which further transduce these signals intracellular to appropriate downstream effectors and thereby play an important role in various signaling pathways. GPCRs are categorized into six classes based on sequence and function: rhodopsin-like receptors (family A), secretin-like (family B), glutamate (family C), fungal mating pheromone receptors (Class D), cAMP receptors (Class E) and frizzled/smoothened (Class F). Class B GPCRs (secretin-like receptor family) contains around 70 receptors, including receptors for 15 peptide hormones: vasoactive intestinal peptide receptors (vIPR1, vIPR2), glucagon-like peptide receptors (GLP1R, GLP2R), adenylate cyclase activating polypeptide receptor (PAC1/ADCYAP1R1), growth-hormone-releasing hormone receptor (GHRHR), calcitonin and calcitonin-like receptors (CALCR, CALCRL), gastric inhibitory polypeptide receptor (GIPR), secretin receptor (SCTR), corticotropin-releasing hormone receptors (CRHR1, CRHR2), glucagon receptor (GCGR), and parathyroid hormone receptors (PTHR1, PTHR2). Structurally, class B GPCRs consist of a large N-terminal extracellular domain (ECD) and a transmembrane domain (TMD) comprising the ‘GPCR’ signature of seven membrane spanning α-helices. The class B GPCRs are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (type 2 diabetes, osteoporosis, obesity) and nervous system diseases (migraine, anxiety, depression).

Cat. No. Product Name / Synonyms Species Source
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