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Results for "

selectins

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

3

Inhibitory Antibodies

2

Natural
Products

4

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106139
    Bimosiamose
    2 Publications Verification

    TBC-1269

    P-selectin Inflammation/Immunology
    Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .
    Bimosiamose
  • HY-P99263

    Anti-Human selectin P Recombinant Antibody

    P-selectin Cardiovascular Disease
    Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion .
    Inclacumab
  • HY-103358

    P-selectin Inflammation/Immunology
    KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM .
    KF38789
  • HY-P9987

    P-selectin Cardiovascular Disease
    Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .
    Crizanlizumab
  • HY-106139A

    TBC-1269Z

    P-selectin Inflammation/Immunology
    Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects .
    Bimosiamose disodium
  • HY-100226

    A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases .
    A-205804
  • HY-15526
    PSI-697
    5 Publications Verification

    P-Selectin Inhibitor

    P-selectin Cancer
    PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM .
    PSI-697
  • HY-160072

    Others Cancer
    Fmoc-NH-PEG2-NHS ester is an intermediate used in the synthesis of E-selectin antagonists [1] .
    Fmoc-NH-PEG2-NHS ester
  • HY-W020790

    sLeX

    Endogenous Metabolite Inflammation/Immunology
    Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .
    Sialyl-Lewis X
  • HY-U00003

    Integrin Inflammation/Immunology
    ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.
    ICAM-1-IN-1
  • HY-125475

    GMI-1070

    Others Cardiovascular Disease
    Rivipansel (GMI-1070) is a potent E-selectin antagonist. Rivipansel prevents interaction between leukocytes and vascular endothelium. Rivipansel has the potential for the research of sickle cell vaso-occlusive crisis .
    Rivipansel
  • HY-132828

    DHDMIQK(KAP)

    P-selectin Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    Odatroltide, as a nanoscale P-selectin inhibitor, is a nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus .
    Odatroltide
  • HY-N0250
    Saikosaponin D
    2 Publications Verification

    STAT NF-κB Estrogen Receptor/ERR Bacterial Infection Inflammation/Immunology Cancer
    Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
    Saikosaponin D
  • HY-N1480S

    6-Desoxygalactose-13C; L-(-)-Fucose-13C; L-Galactomethylose-13C

    Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]
    (-)-Fucose-13C
  • HY-N1480S1

    6-Desoxygalactose-13C-1; L-(-)-Fucose-13C-1; L-Galactomethylose-13C-1

    Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-1
  • HY-N1480S2

    6-Desoxygalactose-13C-2; L-(-)-Fucose-13C-2; L-Galactomethylose-13C-2

    Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-2
  • HY-N1480S3

    6-Desoxygalactose-13C-3; L-(-)-Fucose-13C-3; L-Galactomethylose-13C-3

    Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-3
  • HY-N1480

    6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose

    (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth .
    (-)-Fucose
  • HY-13965
    Parmodulin 2
    2 Publications Verification

    ML161

    Protease Activated Receptor (PAR) Cardiovascular Disease
    Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM . Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo .
    Parmodulin 2
  • HY-146332

    Others Cardiovascular Disease
    Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .
    Collagen-IN-1

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