1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear receptor superfamily
  4. Thyroid hormone receptors

Thyroid hormone receptors

Thyroid hormone receptors (THRs) are members of the nuclear receptor superfamily that includes the glucocorticoid, estrogen, progesterone, androgen, aldosterone, vitamin D, retinoic acid (RARs), retinoid X (RXRs) and "orphan" (unknown ligand and/or DNA target) receptors. The vertebrate THRs are encoded by two genes located on different chromosomes, NR1A1 (TRα gene) and NR1A2 (TRβ gene), although due to ancestral gene duplication, some nonmammalian vertebrate species, including teleost fish, have two TRα-encoding genes. In mammals, the predominant isoforms generated by alternative splicing mechanisms include the bona fide nuclear receptors TRα1, TRβ1, TRβ2, TRβ3 and TRβ4, which are able to bind T3, and the nonreceptor TR variants that lack T3-binding ability, TRα2, TRα3 and TRα-∆E6. THRs mediate the action of thyroid hormone signaling to regulate many aspects of development, growth and metabolism, and mitochondrial activity. (Targeting Thyroid Hormone Receptor )