1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-1R
  5. Type I IL-1 Receptor (IL-1R1)

Type I IL-1 Receptor (IL-1R1)

IL-1R1 (CD121a), a member of IL-1 receptor, is a receptor for IL-1α, IL-1β, IL-1Ra and IL-38[1]. IL-1R1 mediates immune and inflammatory responses.IL-1R1 mediates IL-1-dependent activation, including the activation of NF-κB and MAPK pathway[2]. IL-1R1 is expressed in specific endothelial cells, ventricular cells, astrocytes, and neurons[3]. Human IL-1R1 consists of extracellular domain (L18-K336), helical domain (H337-Y356), and cytoplasmic domain (K357-G569).Human IL-1R1 shares <70% aa sequence identity with mouse and rats. Rats IL-1R1 shares 85.59% aa sequence identity with mouse. IL-1R1 binds to IL-1 by forming a heterodimer with IL-1R3 (IL-1RAcP). The heterodimer is responsible for the signal transduction by the hydrolysis of GTP, followed by the activation of JNK and p38 MAP kinase[4]. Upon binding of IL-1, IL-1R1 initiates the downstream signaling cascade (MAPK p38 and NF-κB pathway)[2].

Cat. No. Product Name / Synonyms Species Source
  • HY-P74822
    IL-1R1 Protein, Rat (HEK293, His)

    Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1

    Rat HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB, MAPK pathways . IL-1R1 Protein, Rat (HEK293, His) is a recombinant rat extracellular region of IL-1R1 (M1-K352) with a C terminal His tag, which is produced in HEK293 cells.
  • HY-P70286
    IL-1R1 Protein, Mouse (HEK293, His)

    rMuInterleukin-1 receptor type 1/IL-1R1, His ; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1 RI; CD121a

    Mouse HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Mouse (HEK293, His) is a recombinant mouse extracellular region of IL-1R1 (L20-K338) with a C terminal 6*His tag, which is produced in HEK293 cells.
  • HY-P72569
    IL-1R1 Protein, Human (315a.a, HEK293, His)

    Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; Interleukin-1 receptor alpha; IL-1R-alpha; p80; CD121a    

    Human HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Human (315a.a, HEK293, His) is a recombinant human extracellular region of IL-1R1 (L18-T332) with a C-Terminal 6*His tag, which is produced in HEK293 cells.
  • HY-P74823
    IL-1R1 Protein, Human (HEK293)

    Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1

    Human HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. I IL-1R1 Protein, Human (HEK293) is a recombinant human extracellular region of IL-1R1 (M1-T332) without any tag, which is produced in HEK293 cells.
  • HY-P76996
    IL-1R1 Protein, Cynomolgus (HEK293, His)

    Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1

    Cynomolgus HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus extracellular region of IL-1R1 (M1-T332) with a C-Terminal His tag, which is produced in HEK293 cells.
  • HY-P71876A
    IL-1RN Protein, Horse (His)

    IL1RN; IL1RAInterleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor

    Equine E. coli
    IL-1RN protein, an anti-inflammatory antagonist, safeguards against immune dysregulation and systemic inflammation triggered by IL1. It acts on proinflammatory cytokines, including IL1B and IL1A, countering the effects of IL1. Particularly responsive to innate stimulatory agents like pathogens, IL-1RN helps mitigate the inflammatory response, ensuring immune homeostasis. IL-1RN Protein, Horse (His) is the recombinant equine-derived IL-1RN protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-1RN Protein, Horse (His) is 152 a.a., with molecular weight of ~18 kDa.
  • HY-P73894A
    IL-1RA/IL-1RN Protein, Rat (C-His)

    Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; Il1rn

    Rat E. coli
    The IL-1RA/IL-1RN mutant protein, an enhanced anti-inflammatory antagonist in the interleukin-1 family, specifically targets proinflammatory cytokines IL1B and IL1A. Engineered for increased inhibitory capabilities, this mutant variant critically safeguards the host from immune dysregulation and prevents uncontrolled systemic inflammation triggered by IL1 in response to innate stimulatory agents. Offering optimized defense against IL1-mediated inflammation, the mutant protein significantly contributes to maintaining immune balance and preventing excessive inflammation. IL-1RA/IL-1RN Protein, Rat (C-His) is the recombinant rat-derived IL-1RA/IL-1RN protein, expressed by E. coli, with C-6*His labeled tag. The total length of IL-1RA/IL-1RN Protein, Rat (C-His) is 152 a.a., with molecular weight of ~19.94 kDa.
  • HY-P73185
    IL-1R1 Protein, Human (HEK293, Fc)

    Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1

    Human HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-1R1 (M1-T332) with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P76995
    IL-1R1 Protein, Cynomolgus (HEK293, Fc)

    Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1

    Cynomolgus HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus extracellular region of IL-1R1 (M1-T332) with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P74821
    IL-1R1 Protein, Rat (HEK293, His-mFc)

    Interleukin-1 receptor type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1

    Rat HEK293
    IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB, MAPK pathways. IL-1R1 Protein, Rat (HEK293, His-mFc) is a recombinant rat extracellular region of IL-1R1 (M1-K352) with C terminal His and hFc tags, which is produced in HEK293 cells.
Cat. No. Product Name Effect Purity