1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. Type II IFNs

Type II interferon (IFN) consists of IFN-γ only. As a part of the innate immune response, IFN-γ is predominantly produced by natural killer (NK) cells during the antiviral innate immune response. IFN-γ binds a cell-surface receptor, the type II IFN receptor which is composed of two subunits, IFNGR1 and IFNGR2. The IFNGR1 subunit associates with JAK1, whereas IFNGR2 is constitutively associated with JAK2. Ligation of IFN-γ to the IFNGR activates the JAK/STAT1 pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions. However, like type I IFN, IFN-γ has also been shown to signal through alternative pathways, including STAT4, Erk1/2, Pyk2, and CrkL, among others. IFN-γ can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance, and control cellular proliferation and apoptosis.

Cat. No. Product Name / Synonyms Species Source
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