1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. Type III IFNs

Type III interferons (IFNs) (or IFN-λs) comprise four members in human (IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4) and two in mice (IFN-λ2 and IFN-λ3, while IFN-λ1 is a pseudogene). IFN-λ1, -λ2 and -λ3 were discovered as interleukin-29 (IL-29), IL-28A and IL-28B, respectively. IFN-λs signal via a heterodimeric IFN-λ receptor (IFNLR or IL-28R), which is composed of two subunit, IFN-λR1 (IL28RA) and IL-10R2 (IL-10Rβ). IL-10R2 subunit is common to many type II cytokines, such as IL-10, IL-22, IL-24, and IL-26. Although distinct receptor is engaged, IFN-λs trigger type I-IFN-like immune responses. In fact, both signal through the JAK-STAT pathway resulting in the activation of the same ISGF3 transcription complex and expression of ISGs many of which encode proteins with antiviral functions. IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target cells with a high risk viral exposure and infection, such as those at mucosal surfaces, and protect them against the frequent viral attacks that are typical for barrier tissues.

Cat. No. Product Name / Synonyms Species Source
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