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Products are for research use only. Not for human use. We do not sell to patients.
(R 1479; 4'-Azidocytidine; R1479)
R-1479 Chemical Structure
|Product name: R-1479|
|Cat. No.: HY-10444|
R1479 (4'-azidocytidine), is a potent and highly specific inhibitor of HCV replication in cell culture, and that its triphosphate is a potent and highly selective inhibitor of NS5B mediated RNA synthesis, the HCV encoded RNA polymerase.
IC50 Value: 1.28 uM (HCV replicon assay) 
in vitro: R1479 (4'-azidocytidine) is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC(50) = 1.28 microM) with similar potency compared with 2'-C-methylcytidine (IC(50) = 1.13 microM). R1479 showed no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at concentrations up to 2 mM. HCV replicon RNA could be fully cleared from replicon cells after prolonged incubation with R1479 .
Toxicity: R1479 displayed good activity in the replicon assay with no measurable cytotoxic or cytostatic effect .
Clinical trial: A Study of Balapiravir in Patients With Dengue Virus Infection. Phase 1
|M.Wt||284.23||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||3.5183 mL||17.5914 mL||35.1828 mL|
|5 mM||0.7037 mL||3.5183 mL||7.0366 mL|
|10 mM||0.3518 mL||1.7591 mL||3.5183 mL|
. Smith DB, et al. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6.
. Klumpp K, et al. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9.
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