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R-1479

HY-10444

(R 1479; 4'-Azidocytidine; R1479)

R-1479

R-1479 Chemical Structure

R1479 (4'-azidocytidine), is a potent and highly specific inhibitor of HCV replication in cell culture, and that its triphosphate is a potent and highly selective inhibitor of NS5B mediated RNA synthesis, the HCV encoded RNA polymerase.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €377 In-stock
5 mg €343 In-stock
10 mg €490 In-stock
50 mg €1470 In-stock
100 mg €2058 In-stock
200 mg Get quote
500 mg Get quote

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Product name: R-1479
Cat. No.: HY-10444

R-1479 Data Sheet

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    Purity: 99.14%

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    DataSheet

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Biological Activity of R-1479

R1479 (4'-azidocytidine), is a potent and highly specific inhibitor of HCV replication in cell culture, and that its triphosphate is a potent and highly selective inhibitor of NS5B mediated RNA synthesis, the HCV encoded RNA polymerase.
IC50 Value: 1.28 uM (HCV replicon assay) [1]
Target: HCV
in vitro: R1479 (4'-azidocytidine) is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC(50) = 1.28 microM) with similar potency compared with 2'-C-methylcytidine (IC(50) = 1.13 microM). R1479 showed no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at concentrations up to 2 mM. HCV replicon RNA could be fully cleared from replicon cells after prolonged incubation with R1479 [2].
in vivo:
Toxicity: R1479 displayed good activity in the replicon assay with no measurable cytotoxic or cytostatic effect [1].
Clinical trial: A Study of Balapiravir in Patients With Dengue Virus Infection. Phase 1
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 284.23 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C9H12N6O5
CAS No 478182-28-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.5183 mL 17.5914 mL 35.1828 mL
5 mM 0.7037 mL 3.5183 mL 7.0366 mL
10 mM 0.3518 mL 1.7591 mL 3.5183 mL

References on R-1479

Inhibitor Kit

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