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(R)-Fadrozole (Synonyms: (R)-CGS 16949A free base; FAD286)

Cat. No.: HY-113986
Handling Instructions

(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..

For research use only. We do not sell to patients.

(R)-Fadrozole Chemical Structure

(R)-Fadrozole Chemical Structure

CAS No. : 102676-87-9

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Description

(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor[1]. (R)-Fadrozole also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].

IC50 & Target

pIC50: 6.17 (human placental aromatase)

In Vitro

The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of (R)-Fadrozole[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(R)-fadrozole (0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2].
(R)-fadrozole (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SHHF rats[2]
Dosage: 0.24 and 1.2 mg/kg
Administration: Daily; oral
Result: Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
Molecular Weight

223.27

Formula

C₁₄H₁₃N₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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(R)-Fadrozole
Cat. No.:
HY-113986
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