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Dexfadrostat  (Synonyms: (R)-Fadrozole; (R)-CGS 16949A free base; FAD286)

Cat. No.: HY-113986
Handling Instructions

Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..

For research use only. We do not sell to patients.

Dexfadrostat Chemical Structure

Dexfadrostat Chemical Structure

CAS No. : 102676-87-9

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Description

Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].

IC50 & Target

pIC50: 6.17 (human placental aromatase)

In Vitro

The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of Dexfadrostat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2].
Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SHHF rats[2]
Dosage: 0.24 and 1.2 mg/kg
Administration: Daily; oral
Result: Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
Molecular Weight

223.27

Formula

C14H13N3

CAS No.
SMILES

N#CC1=CC=C([[email protected]]2CCCC3=CN=CN23)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dexfadrostat
Cat. No.:
HY-113986
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