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(R)-PQ-912 

Cat. No.: HY-123821B Purity: 99.76% ee.: 99.69%
Handling Instructions

(R)-PQ-912 is a glutaminyl cyclase (QC) inhibitor extracted from patent WO2011029920A1, example 13, has an IC50 of 30.2 μM and a Ki of 7.25 μM for hQC.

For research use only. We do not sell to patients.

(R)-PQ-912 Chemical Structure

(R)-PQ-912 Chemical Structure

CAS No. : 1276021-64-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

(R)-PQ-912 is a glutaminyl cyclase (QC) inhibitor extracted from patent WO2011029920A1, example 13, has an IC50 of 30.2 μM and a Ki of 7.25 μM for hQC[1].

Molecular Weight

336.39

Formula

C₁₉H₂₀N₄O₂

CAS No.

1276021-64-7

SMILES

O=C1NC[[email protected]@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4N=CNC4=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (594.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.76% ee.: 99.69%

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Product Name:
(R)-PQ-912
Cat. No.:
HY-123821B
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