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  3. Rac-PQ-912

Rac-PQ-912 

Cat. No.: HY-123821A
Handling Instructions

Rac-PQ-912 is a glutaminyl cyclase (QC) inhibitor extracted from patent WO2011029920A1, compound example 12, has an EC50 of 482 nM and a Ki of 62.5 nM for hQC.

For research use only. We do not sell to patients.

Rac-PQ-912 Chemical Structure

Rac-PQ-912 Chemical Structure

CAS No. : 1276021-63-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

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Description

Rac-PQ-912 is a glutaminyl cyclase (QC) inhibitor extracted from patent WO2011029920A1, compound example 12, has an EC50 of 482 nM and a Ki of 62.5 nM for hQC[1].

IC50 & Target

EC50: 482 nM (hQC)
Ki: 62.5 nM (hQC)[1]

Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (594.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (14.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

336.39

Formula

C₁₉H₂₀N₄O₂

CAS No.

1276021-63-6

SMILES

O=C1NCC(C2=CC=C(OCCC)C=C2)N1C3=CC=C4N=CNC4=C3

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Rac-PQ-912
Cat. No.:
HY-123821A
Quantity:

Rac-PQ-912

Cat. No.: HY-123821A