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  3. Rachelmycin

Rachelmycin (Synonyms: CC-1065; NSC 298223)

Cat. No.: HY-12457
Handling Instructions

Rachelmycin (CC-1065; NSC 298223) is a potent naturally antibiotic isolated from Streptomyces zelensis. Rachelmycin binds non-covalently and covalently (N-3 adenine adduct) in the minor groove of B-form DNA. Rachelmycin has exceptionally potent antitumor activity.

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Rachelmycin Chemical Structure

Rachelmycin Chemical Structure

CAS No. : 69866-21-3

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Description

Rachelmycin (CC-1065; NSC 298223) is a potent naturally antibiotic isolated from Streptomyces zelensis. Rachelmycin binds non-covalently and covalently (N-3 adenine adduct) in the minor groove of B-form DNA. Rachelmycin has exceptionally potent antitumor activity[1].

In Vivo

The smallest dose at which delayed death occurs is less for Rachelmycin (CC-1065; NSC 298223; 12.5 mg/kg) in experiments with non-tumored BDF1 mice[1].

Molecular Weight

703.70

Formula

C₃₇H₃₃N₇O₈

CAS No.

69866-21-3

SMILES

O=C(N1C2=C(O)C(OC)=C3NC(C(N4C5=C(O)C(OC)=C6NC(C(N7C[[email protected]](C8)([H])[[email protected]]98C%10=C(NC=C%10C)C(C=C79)=O)=O)=CC6=C5CC4)=O)=CC3=C2CC1)N

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RachelmycinCC-1065NSC 298223CC1065CC 1065NSC298223NSC-298223AntibioticStreptomyceszelensisminorgrooveB-formDNAantitumorInhibitorinhibitorinhibit

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