Rachelmycin  (Synonyms: CC-1065; NSC 298223)

Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research^[1][2][3].

CC-1065 inhibits DNA synthesis, and effects the progression of the cell cycle by blocking cell cycle in G2+M phases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rachelmycin (13.5-250 mg/kg; i.p., once daily for 3-9 times) inhibits tumor growth in a variety of mouse tumor models, such as: P388, ADJ-PC6, B16, CD8F1, Colon 26 and L1210 systems^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

703.70

C₃₇H₃₃N₇O₈

69866-21-3

O=C(N1C2=C(O)C(OC)=C3NC(C(N4C5=C(O)C(OC)=C6NC(C(N7C[C@](C8)([H])[C@]98C%10=C(NC=C%10C)C(C=C79)=O)=O)=CC6=C5CC4)=O)=CC3=C2CC1)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. W C Krueger, et al. Calf Thymus DNA binding/bonding Properties of CC-1065 and Analogs as Related to Their Biological Activities and Toxicities. Chem Biol Interact. 1992 Mar;82(1):31-46.  [Content Brief]

  [2]. Martin DG, et al. CC-1065 (NSC 298223), a potent new antitumor agent improved production and isolation, characterization and antitumor activity. J Antibiot (Tokyo). 1981 Sep;34(9):1119-25.  [Content Brief]

  [3]. Reynolds VL, et al. The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic. J Antibiot (Tokyo). 1986 Mar;39(3):319-34.  [Content Brief]