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  4. 15-PGDH/HPGD Protein, Human (His)

15-PGDH/HPGD Protein, Human (His)

Cat. No.: HY-P75547
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15-PGDH/HPGD, a short-chain nonmetalloenzyme alcohol dehydrogenase, is crucial for prostaglandin metabolism, influencing various physiological and cellular processes like inflammation. Mutations lead to hypertrophic osteoarthropathy. Biased expression in urinary bladder (RPKM 176.8) and stomach (RPKM 67.9), among other tissues. Multiple isoforms arise from various transcript variants. 15-PGDH/HPGD Protein, Human (His) is the recombinant human-derived 15-PGDH/HPGD protein, expressed by E. coli , with C-His labeled tag. The total length of 15-PGDH/HPGD Protein, Human (His) is 266 a.a., with molecular weight of ~27 kDa.

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Description

15-PGDH/HPGD, a short-chain nonmetalloenzyme alcohol dehydrogenase, is crucial for prostaglandin metabolism, influencing various physiological and cellular processes like inflammation. Mutations lead to hypertrophic osteoarthropathy. Biased expression in urinary bladder (RPKM 176.8) and stomach (RPKM 67.9), among other tissues. Multiple isoforms arise from various transcript variants. 15-PGDH/HPGD Protein, Human (His) is the recombinant human-derived 15-PGDH/HPGD protein, expressed by E. coli , with C-His labeled tag. The total length of 15-PGDH/HPGD Protein, Human (His) is 266 a.a., with molecular weight of ~27 kDa.

Background

15-PGDH/HPGD Protein, a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family, plays a crucial role in the metabolism of prostaglandins, contributing to various physiological and cellular processes, including inflammation. Mutations in this gene are associated with primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy, underscoring its significance in maintaining normal skeletal development. The gene exhibits multiple transcript variants, encoding different isoforms, adding to the functional diversity of the encoded enzyme. Notably, 15-PGDH/HPGD demonstrates biased expression, with heightened levels observed in the urinary bladder (RPKM 176.8), stomach (RPKM 67.9), and 11 other tissues, suggesting its specialized roles in these tissues and its potential involvement in diverse physiological contexts.

Species

Human

Source

E. coli

Tag

C-His

Accession

NP_000851.2 (M1-Q266)

Gene ID
Molecular Construction
N-term
15-PGDH (M1-Q266)
Accession # NP_000851.2
His
C-term
Synonyms
15-hydroxyprostaglandin dehydrogenase [NAD(+)]; HPGD; PGDH1; SDR36C1
Molecular Weight

Approximately 27 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

15-PGDH/HPGD Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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15-PGDH/HPGD Protein, Human (His)
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HY-P75547
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