1. Recombinant Proteins
  2. Receptor Proteins
  3. G-Protein-Coupled Receptors (GPCRs)
  4. CT Receptor (Calcitonin Receptor)
  5. Calcitonin R Protein, Human (HEK293, Fc)

Calcitonin R Protein, Human (HEK293, Fc)

Cat. No.: HY-P74358
Handling Instructions

Calcitonin R protein, a receptor for calcitonin, utilizes G proteins to activate adenylyl cyclase. Despite being sensitive to cholera toxin, it exhibits limited coupling to G proteins, leading to the inability to effectively activate adenylyl cyclase. Notably, following ligand binding, Calcitonin R does not undergo the conventional process of receptor internalization. Calcitonin R Protein, Human (HEK293, Fc) is the recombinant human-derived Calcitonin R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Calcitonin R Protein, Human (HEK293, Fc) is 129 a.a., with molecular weight of ~42.1 kDa.

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Description

Calcitonin R protein, a receptor for calcitonin, utilizes G proteins to activate adenylyl cyclase. Despite being sensitive to cholera toxin, it exhibits limited coupling to G proteins, leading to the inability to effectively activate adenylyl cyclase. Notably, following ligand binding, Calcitonin R does not undergo the conventional process of receptor internalization. Calcitonin R Protein, Human (HEK293, Fc) is the recombinant human-derived Calcitonin R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Calcitonin R Protein, Human (HEK293, Fc) is 129 a.a., with molecular weight of ~42.1 kDa.

Background

The Calcitonin R protein serves as a receptor for calcitonin, exerting its activity through G proteins that subsequently activate adenylyl cyclase. This receptor is believed to couple with a heterotrimeric G protein sensitive to cholera toxin. However, it is noteworthy that while the Calcitonin R serves as a receptor for calcitonin, it does not effectively couple to G proteins, resulting in the inability to activate adenylyl cyclase. Additionally, following ligand binding, this receptor does not undergo the typical process of receptor internalization.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P30988 (A25-I153)

Gene ID

799  [NCBI]

Molecular Construction
N-term
CALCR (A25-I153)
Accession # P30988
hFc
C-term
Synonyms
Calcitonin R; Calcitonin receptor; CALCR; CRT; CTR; CTR1
Molecular Weight

Approximately 42.1 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Calcitonin R Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Calcitonin R Protein, Human (HEK293, Fc)
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HY-P74358
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