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  5. CD276/B7-H3 Protein, Human (HEK293, His-Avi)

CD276/B7-H3 Protein, Human (HEK293, His-Avi)

Cat. No.: HY-P78391
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CD276/B7-H3 Protein may regulate T-cell-mediated immune responses, acting as a protective factor in tumor cells by inhibiting natural-killer-mediated cell lysis. It also serves as a neuroblastoma cell marker and plays a role in acute and chronic transplant rejection, regulating lymphocytic activity at mucosal surfaces. Crucially, CD276/B7-H3 may provide an immunologically suitable environment for the placenta and fetus during pregnancy. Both isoforms modulate CD4 T-cell responses, with isoform 2 enhancing cytotoxic T-cells and selectively stimulating interferon-gamma production. Interaction with TREML2 enhances T-cell activation, highlighting CD276/B7-H3's diverse roles in immune regulation and cellular responses. CD276/B7-H3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD276/B7-H3 Protein, Human (HEK293, His-Avi) is 435 a.a., with molecular weight of 70-80 kDa.

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Description

CD276/B7-H3 Protein may regulate T-cell-mediated immune responses, acting as a protective factor in tumor cells by inhibiting natural-killer-mediated cell lysis. It also serves as a neuroblastoma cell marker and plays a role in acute and chronic transplant rejection, regulating lymphocytic activity at mucosal surfaces. Crucially, CD276/B7-H3 may provide an immunologically suitable environment for the placenta and fetus during pregnancy. Both isoforms modulate CD4 T-cell responses, with isoform 2 enhancing cytotoxic T-cells and selectively stimulating interferon-gamma production. Interaction with TREML2 enhances T-cell activation, highlighting CD276/B7-H3's diverse roles in immune regulation and cellular responses. CD276/B7-H3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD276/B7-H3 Protein, Human (HEK293, His-Avi) is 435 a.a., with molecular weight of 70-80 kDa.

Background

The CD276/B7-H3 protein is suggested to play a multifaceted role in the regulation of T-cell-mediated immune responses, potentially acting as a protective factor in tumor cells by inhibiting natural-killer-mediated cell lysis and serving as a marker for the detection of neuroblastoma cells. Additionally, CD276/B7-H3 may be involved in the development of acute and chronic transplant rejection, contributing to the regulation of lymphocytic activity at mucosal surfaces. Notably, it could play a crucial role in providing the placenta and fetus with an immunologically suitable environment throughout pregnancy. Both isoform 1 and isoform 2 of CD276/B7-H3 appear redundant in their ability to modulate CD4 T-cell responses, with isoform 2 demonstrated to enhance the induction of cytotoxic T-cells and selectively stimulate interferon-gamma production in the presence of T-cell receptor signaling. The interaction with TREML2 is identified as enhancing T-cell activation, highlighting the diverse roles CD276/B7-H3 may play in immune regulation and cellular responses.

Species

Human

Source

HEK293

Tag

C-Avi;C-His

Accession

Q5ZPR3 (G27-T461)

Gene ID
Molecular Construction
N-term
CD276 (G27-T461)
Accession # Q5ZPR3
His-Avi
C-term
Synonyms
B7-H3; CD276; PSEC0249;  4Ig-B7-H3; UNQ309; PRO352; B7 homolog 3; CD276
Molecular Weight

70-80 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
CD276/B7-H3 Protein, Human (HEK293, His-Avi)
Cat. No.:
HY-P78391
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