2. Recombinant Proteins
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins
  5. CD300a
  6. CD300a/LMIR1 Protein, Human (178a.a, HEK293, His)

CD300a/LMIR1 Protein, Human (178a.a, HEK293, His)

Cat. No.: HY-P75636
Handling Instructions

CD300a/LMIR1 Protein, an inhibitory receptor, potentially diminishes cytolytic activity in NK cells and suppresses mast cell degranulation. It serves as a negative regulator in MYD88-mediated TLR signaling, activating PTPN6 but not TRIF. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D, showcasing its multifaceted involvement in immune regulation and cellular responses. CD300a/LMIR1 Protein, Human (178a.a, HEK293, His) is the recombinant human-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD300a/LMIR1 Protein, Human (178a.a, HEK293, His) is 178 a.a., with molecular weight of 33-43 kDa.

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Description

CD300a/LMIR1 Protein, an inhibitory receptor, potentially diminishes cytolytic activity in NK cells and suppresses mast cell degranulation. It serves as a negative regulator in MYD88-mediated TLR signaling, activating PTPN6 but not TRIF. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D, showcasing its multifaceted involvement in immune regulation and cellular responses. CD300a/LMIR1 Protein, Human (178a.a, HEK293, His) is the recombinant human-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD300a/LMIR1 Protein, Human (178a.a, HEK293, His) is 178 a.a., with molecular weight of 33-43 kDa.
Background

CD300a/LMIR1, an inhibitory receptor, potentially plays a role in diminishing cytolytic activity in natural killer (NK) cells and suppressing mast cell degranulation. Additionally, it acts as a negative regulator in Toll-like receptor (TLR) signaling mediated by MYD88, although not TRIF, by activating PTPN6. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1 and PTPN11/SHP-2, as well as INPP5D, illustrating its multifaceted involvement in immune regulation and cellular responses.
Species

Human
Source

HEK293
Tag

C-His
Accession

Q9UGN4 (M1-Q178)
Gene ID
Molecular Construction
N-term
CD300A (M1-Q178)
Accession # Q9UGN4
His
C-term
Synonyms
CMRF35-like molecule 8; CLM-8; MAIR-1; CD300a; IGSF12
Molecular Weight

33-43 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CD300a/LMIR1 Protein, Human (178a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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