2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Growth Differentiation Factor
  6. Growth Differentiation Factor-8 (GDF-8)
  7. GDF-8 Protein, Mouse (HEK293, Fc)

GDF-8 Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P74127
COA Handling Instructions

The GDF-8 protein, also known as myostatin, negatively regulates skeletal muscle growth. It acts as a disulfide-linked homodimer and inhibits its activity by interacting with WFIKKN2. Additionally, it interacts with FSTL3. GDF-8 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GDF-8 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of GDF-8 Protein, Mouse (HEK293, Fc) is 109 a.a., with molecular weight of ~45 kDa.

For research use only. We do not sell to patients.

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Description

The GDF-8 protein, also known as myostatin, negatively regulates skeletal muscle growth. It acts as a disulfide-linked homodimer and inhibits its activity by interacting with WFIKKN2. Additionally, it interacts with FSTL3. GDF-8 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GDF-8 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of GDF-8 Protein, Mouse (HEK293, Fc) is 109 a.a., with molecular weight of ~45 kDa.
Background

The GDF-8 protein, also known as myostatin, acts specifically as a negative regulator of skeletal muscle growth. It functions as a homodimer that is disulfide-linked. Additionally, it interacts with WFIKKN2, leading to the inhibition of its activity. Furthermore, it has been found to interact with FSTL3.
Species

Mouse
Source

HEK293
Tag

N-hFc
Accession

Q540E2 (D268-S376)
Gene ID

17700  [NCBI]
Molecular Construction
N-term
hFc
GDF-8 (D268-S376)
Accession # Q540E2
C-term
Synonyms
Growth/differentiation factor 8; GDF-8; Myostatin; MSTN
Molecular Weight

Approximately 45 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Solution
Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.
Reconstitution

N/A.
Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.
Documentation

COA (220 KB)

Handling Instructions (2659 KB)

GDF-8 Protein, Mouse (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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