HDAC4 Protein, Human (sf9)

The HDAC4 protein deacetylates core histones, thereby affecting transcription, cell cycle, and development. During muscle maturation, HDAC4 interacts with myocyte enhancer factors (MEF2A, MEF2C, and MEF2D). HDAC4 Protein, Human (sf9) is the recombinant human-derived HDAC4 protein, expressed by Sf9 insect cells , with tag free. The total length of HDAC4 Protein, Human (sf9) is 473 a.a., with molecular weight of ~51 kDa.

The HDAC4 protein plays a crucial role in the deacetylation of lysine residues on the N-terminal region of core histones (H2A, H2B, H3, and H4), contributing to the epigenetic repression that underlies essential cellular processes, including transcriptional regulation, cell cycle progression, and developmental events. Functioning within large multiprotein complexes, histone deacetylases, including HDAC4, orchestrate these intricate regulatory mechanisms. Specifically, HDAC4 is involved in muscle maturation through its interaction with myocyte enhancer factors (MEF2A, MEF2C, and MEF2D). Furthermore, HDAC4 plays a pivotal role in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Notably, HDAC4 deacetylates HSPA1A and HSPA1B at 'Lys-77,' leading to their preferential binding to the co-chaperone STUB1, demonstrating the protein's diverse and nuanced involvement in cellular processes and molecular interactions.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

Sf9 insect cells

Tag Free

P56524 (M612-L1084)

9759  [NCBI]

Approximately 51 kDa

Greater than 90% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.