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il-23-protein-human-hek-293-his

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Compare Product Name Species Source
  • HY-P70736
    IL-23 Protein, Human (HEK293, His)

    il-23 alpha (306a.a) & il-12 beta (170a.a) Heterodimer; SGRF; il-23p19; CLMF p40; il-12 subunit p40; NKSF2

    		 Human HEK293
    IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. IL-23 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 protein, expressed by HEK293, with C-6*His labeled tag. IL-23 Protein, Human (HEK293, His), has molecular weight of approximately 63.08 kDa.

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