1. Recombinant Proteins
  2. IL-2R alpha Protein, Human (HEK293, Fc)

IL-2R alpha Protein, Human (HEK293, Fc)

Cat. No.: HY-P70629
Handling Instructions

IL-2R alpha Protein, Human (HEK293, Fc), a recombinant human IL-2RA produced in HEK293 cells, has an Fc fragment at the C-terminus. IL-2RA is a subunit of interleukin-2 receptor, plays a critical role in regulating the IL-2-mediated responses by modulating the affinity of the IL-2R for the ligand[1].

For research use only. We do not sell to patients.

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Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $150 In-stock
Estimated Time of Arrival: December 31
50 μg $450 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
IL-2R alpha; IL-2RA; IL-2 R alpha; Interleukin-2 receptor subunit alpha; CD25; p55; TAC antigen; IL2-RA; IL-2R subunit alpha; IL-2-RA; IL-2 receptor subunit alpha
Species

Human

Source

HEK 293

Accession

P01589(E22-C213)

Gene ID

3559

Molecular Weight

60-80 kDa

AA Sequence

ELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSC

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity
10 μg/mL (100 μL/well) of immobilized Human IL-2RA-Fc can bind Human IL-2-His with an ED50 value of 0.46 μg/mL.
Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

Reconstitute at 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Background

IL-2 binds with high affinity to a receptor consisting of three subunits: IL-2Rα (CD25), IL-2Rβ (CD122) and γc (CD132). Alpha subunit plays a critical role in regulating the IL-2-mediated responses by modulating the affinity of the IL-2R for the ligand. Then, two β and γ subunits initiate the signal transduction process via cytoplasmic tails[1].

Documentation
References
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Product Name:
IL-2R alpha Protein, Human (HEK293, Fc)
Cat. No.:
HY-P70629
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