1. Recombinant Proteins
  2. IL-36 alpha /IL-1 F6 Protein, Human (153a.a)

IL-36 alpha /IL-1 F6 Protein, Human (153a.a)

Cat. No.: HY-P70702
Handling Instructions

IL-36 alpha /IL-1 F6 Protein, Human (153a.a) is proinflammatory and have an important role in innate and adaptive immunity.

For research use only. We do not sell to patients.

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10 μg $170 Ask For Quote & Lead Time
50 μg $510 Ask For Quote & Lead Time

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  • Technical Parameters

  • Properties

  • Documentation

IL-36 alpha; IL-36α; Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6



E. coli


Q9UHA7 (K6-F158)

Gene ID


Molecular Weight

Approximately 17.0 kDa

AA Sequence



Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity
The cell proliferation assay using A-431 Human epithelial carcinoma cells has an ED50 value of 12 ng/mL.

Lyophilized powder.


Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 0.02% Tween 20, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.


It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.


Room temperature in continental US;may vary elsewhere.


The IL-36 group of cytokines comprises three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ), and one antagonist (IL-36Ra). All members of the IL-36 family use the same receptor (IL-36R), a heterodimer composed of interleukin-1 receptor-like 2 (IL1RL2) as the ligand binding moiety and the IL-1 receptor accessory protein (IL1RAcP). This receptor induces inflammatory responses through MyD88, MAPK, NF-kB, and AP-1 pathways. Constitutive protein expression of IL-36 (α, β, and γ) and their receptor (IL-36R) was found in all cell types. IL-36 cytokines are modulated by microbial components and regulate trophoblast migration and interaction with endothelial cells[1][2].

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This equation is commonly abbreviated as: C1V1 = C2V2

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IL-36 alpha /IL-1 F6 Protein, Human (153a.a)
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