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integrin-alpha-4-beta-1-protein-human-hek293-his-avi

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Integrin (115) Apoptosis (14) Autophagy (4) Bcr-Abl (1) Btk (1) Cholinesterase (ChE) (1) Complement System (2) DYRK (1) EGFR (1) Endogenous Metabolite (2) FAK (4) Free Fatty Acid Receptor (1) Glutaminase (1) Glycoprotein VI (1) HSP (1) Molecular Glues (1) PD-1/PD-L1 (1) PI3K (1) Potassium Channel (1) Src (2) STAT (1)
By Research Areas:	Cancer (71) Cardiovascular Disease (17) Infection (3) Inflammation/Immunology (43) Metabolic Disease (6) Neurological Disease (1)

134

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Integrin 5 alpha Reductase IFNAR α-synuclein PGC-1α Amyloid-β TGF-β Receptor Beta-secretase TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Beta-lactamase Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134130

Integrin modulator 1	Integrin	Inflammation/Immunology
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC₅₀ of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC₅₀ of 12.9 nM .

HY-P2532

Integrin Binding Peptide

Integrin Others

Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation .
HY-18668

Integrin Antagonists 27

Integrin Cancer

Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.

Integrin Binding Peptide	Integrin	Others
Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation .

Integrin Antagonists 27	Integrin	Cancer
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.

HY-163333

*αvβ5 integrin-IN-2*	Integrin Apoptosis	Cancer
αvβ5 integrin-IN-2 (Cpd_AV2) is an αvβ5 integrin inhibitor that disrupts the stability of integrin heterodimers. αvβ5 integrin-IN-2 targets the β-propeller central pocket of ITGAV (integrin αV). αvβ5 integrin-IN-2 induces cellular apoptosis .

HY-130119

Integrin-IN-2	Integrin	Cancer
Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC₅₀ values of 7.8, 8.4, 8.4 and 7.4, respectively .

HY-145363

αvβ5 integrin-IN-1

Integrin Cancer

αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC₅₀ = 8.2) .

*αvβ5 integrin-IN-1*	Integrin	Cancer
αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC₅₀ = 8.2) .

HY-156521

*αvβ1 integrin-IN-2*	Integrin	Others
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC₅₀s of 0.9 nM，and 33 nM，respectively. αvβ1 integrin-IN-2 also inhibits other integrins with ，，IC₅₀s of 380 nM (ανβ3)，280 nM (ανβ5)，230 nM (ανβ6)，87 nM (ανβ8)，respectively，in SPRA assay .

HY-100445

αvβ1 integrin-IN-1

αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects .

*αvβ1 integrin-IN-1*
αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects .

HY-P9911A

*Vedolizumab (anti-α4β7-integrin)*	Integrin	Inflammation/Immunology
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease .

HY-100445A

*αvβ1 integrin-IN-1 TFA* 3 Publications Verification	Integrin	Cardiovascular Disease Cancer
αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects .

HY-48959

*α7β1 integrin* modulator-1**	Integrin	Metabolic Disease
α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy .

HY-153807

*αvβ6 integrin* inhibitor 2**	Integrin	Inflammation/Immunology
αvβ6 integrin inhibitor 2 is a potent ανβ6 integrin inhibitor with an IC₅₀ of 96.5 nM (WO2020081154A1, example 19) .

HY-139702

*α5β1 integrin* agonist-1**	Integrin	Cancer
α5β1 integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.

HY-P3523

KGDS

Integrin Others

KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .

KGDS	Integrin	Others
KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .

HY-P1868

*α2β1 Integrin* Ligand Peptide** DGEA peptide	Integrin	Infection
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors .

HY-P1868A

*α2β1 Integrin* Ligand Peptide TFA** 2 Publications Verification DGEA peptide TFA	Integrin	Others
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors .

HY-150124

K34c

Integrin Cancer

K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research .

K34c	Integrin	Cancer
K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research .

HY-136214

R-BC154 acetate	Integrin	Inflammation/Immunology Cancer
R-BC154 acetate is a selective fluorescent *α₉β₁* integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity .

HY-P0178

LXW7	Integrin	Inflammation/Immunology
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .

HY-P0023

Cyclo(-RGDfK) 5+ Cited Publications	Integrin	Cancer
Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-P0023A

Cyclo(-RGDfK) TFA 5+ Cited Publications	Integrin	Cancer
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-P0178A

LXW7 TFA	Integrin	Inflammation/Immunology
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .

HY-123802

BIO7662

Integrin Cancer

BIO7662 is a specific α4β1 antagonist. BIO7662 can be used to study α4β1 integrin-ligand interactions .

BIO7662	Integrin	Cancer
BIO7662 is a specific *α4β1* antagonist. BIO7662 can be used to study α4β1 integrin-ligand interactions .

HY-P0322

GRGDSPK EMD 56574	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .

HY-P0322A

GRGDSPK TFA EMD 56574 TFA	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption .

HY-P9911

Vedolizumab 1 Publications Verification Anti-human lymphocyte α4β7 integrin, humanized Antibody	Integrin	Inflammation/Immunology Cancer
Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease.

HY-P3732

RGD-4C	Integrin	Cancer
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .

HY-129453

BOP sodium	Integrin	Inflammation/Immunology
BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with K_d values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins .

HY-P99291

Etaracizumab LM 609; MEDI 523; Anti-αvβ3 integrin Recombinant Antibody	Integrin	Cancer
Etaracizumab (LM 609) is an α_vβ₃ integrin IgG1 monoclonal antibody. Etaracizumab inhibits angiogenesis and melanoma tumor growth. Etaracizumab can be used to research anticancer .

HY-P4896

FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro	Integrin	Cancer
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an *integrin* inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .

HY-115677

ILK-IN-3	Integrin DYRK	Cancer
ILK-IN-3 is an orally active integrin linked kinase (ILK) inhibitor. ILK-IN-3 improves the anticancer efficacy of Docetaxel (HY-B0011) in orthotopic LCC6 model .

HY-P3533

EILEVPST	Integrin	Cardiovascular Disease
EILEVPST is a recombinant human fibronectinderived low-molecular-weight peptide fragment. EILEVPST can promote cell type-specific α4 integrin-mediated adhesion. EILEVPST can be used for the research of thrombogenesis .

HY-P1613

Cyclo(Arg-Gly-Asp-D-Phe-Val)	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .

HY-16141

Cilengitide Maximum Cited Publications 38 Publications Verification EMD 121974	Integrin Autophagy Apoptosis STAT PD-1/PD-L1	Cancer
Cilengitide (EMD 121974) is a potent *integrins* antagonist with IC₅₀s of 0.61 nM (α_νβ₃), 8.4 nM (α_νβ₅) and 14.9 nM (α₅β₁), respectively. Cilengitide inhibits the binding of α_νβ₃ and α_νβ₅ to Vitronectin with IC₅₀s of 4 nM and 79 nM, respectively. Cilengitide inhibits *TGF-β/Smad* signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers .

HY-P9984

Etrolizumab rhuMAb beta7; RG7413; PRO145223	Integrin	Cancer
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 *integrin* monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with K_i values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) .

HY-P1613A

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .

HY-W008859

Tetrac 1 Publications Verification Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Integrin Endogenous Metabolite	Cancer
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-P99560

Tadocizumab C4G1; YM-337	Integrin	Cardiovascular Disease
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research .

HY-108831A

Natalizumab (Solution) 1 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab (Solution) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses .

HY-P3448

Certepetide CEND-1; iRGD	Integrin Complement System	Cancer
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with *alphav-integrins* and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .

HY-15770

TR-14035 4 Publications Verification	Integrin	Inflammation/Immunology
TR-14035 is a orally active dual **α₄β₇/α₄β₁ integrin antagonist, with IC₅₀** s of 7 nM and 87 nM for α₄β₇ and α₄β₁, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases .

HY-P99184

Abrilumab	Integrin	Infection Inflammation/Immunology Cancer
Abrilumab is a fully human monoclonal antibody directed against *α4β7. Abrilumab selectively binds the α4β7 integrin* heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .

HY-107588

TC-I 15	Integrin	Cardiovascular Disease
TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin *α2β1* inhibitor with IC₅₀ values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition .

HY-137561

Bexotegrast PLN-74809	Integrin	Inflammation/Immunology
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with K_d of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC₅₀ values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung .

HY-70073

Zaurategrast

2 Publications Verification

CT7758
Integrin Inflammation/Immunology

Zaurategrast (CT7758) is a potent and oral-effective α₄-integrin inhibitor .

Zaurategrast 2 Publications Verification CT7758	Integrin	Inflammation/Immunology
Zaurategrast (CT7758) is a potent and oral-effective *α₄-integrin* inhibitor .

HY-100506

GLPG0187 5 Publications Verification	Integrin	Cancer
GLPG0187 is a broad spectrum *integrin* receptor antagonist with antitumor activity; inhibits α_vβ₁-integrin with an IC₅₀ of 1.3 nM . GLPG0187 inhibits migrasome biogenesis without cytotoxicity .

HY-P0290A

GRGDSP TFA

4 Publications Verification

Integrin Cancer

GRGDSP (TFA) is an integrin inhibitor.

HY-13306

Pyrintegrin 3 Publications Verification	Integrin	Metabolic Disease
Pyrintegrin is an *β1-integrin* agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated *integrin* signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .

HY-111413

c(phg-isoDGR-(NMe)k)

Integrin Cancer

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM .
HY-111413A

c(phg-isoDGR-(NMe)k) TFA

Integrin Cancer

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM .

Cat. No.	Product Name	Target	Research Area

HY-P2532

Integrin Binding Peptide

Integrin Others

Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation .

HY-P10045

Integrin signaling inhibitor, mP13	Peptides	Cardiovascular Disease
Integrin signaling inhibitor, mP13 is an inhibitor of integrin signaling. Integrin signaling inhibitor, mP13 inhibits inside-out and outside-in signaling, including fibrinogen binding, platelet adhesion, and clot retraction .

HY-P6022

*G4RGDSP, integrin-binding peptide*	Peptides	Others
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology

HY-P3523

KGDS

Integrin Others

KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .

HY-P1868

*α2β1 Integrin* Ligand Peptide** DGEA peptide	Integrin	Infection
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors .

HY-P1868A

*α2β1 Integrin* Ligand Peptide TFA** 2 Publications Verification DGEA peptide TFA	Integrin	Others
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors .

HY-P0178

LXW7	Integrin	Inflammation/Immunology
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .

HY-P0023

Cyclo(-RGDfK) Maximum Cited Publications 10 Publications Verification	Integrin	Cancer
Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-P0023A

Cyclo(-RGDfK) TFA Maximum Cited Publications 10 Publications Verification	Integrin	Cancer
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

HY-P0178A

LXW7 TFA	Integrin	Inflammation/Immunology
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .

HY-P0322

GRGDSPK EMD 56574	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .

HY-P0322A

GRGDSPK TFA EMD 56574 TFA	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption .

HY-P3732

RGD-4C	Integrin	Cancer
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .

HY-P4896

FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro	Integrin	Cancer
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an *integrin* inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .

HY-P3533

EILEVPST	Integrin	Cardiovascular Disease
EILEVPST is a recombinant human fibronectinderived low-molecular-weight peptide fragment. EILEVPST can promote cell type-specific α4 integrin-mediated adhesion. EILEVPST can be used for the research of thrombogenesis .

HY-P1613

Cyclo(Arg-Gly-Asp-D-Phe-Val)	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .

HY-P1613A

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .

HY-P3448

Certepetide CEND-1; iRGD	Integrin Complement System	Cancer
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with *alphav-integrins* and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .

HY-P4285

β-Aspartylalanine

Peptides Others

β-Aspartylalanine is a substrate for β-aspartyl peptidase and used to measure β-aspartyl peptidase activity in fecal supernatants .
HY-P0290A

GRGDSP TFA

4 Publications Verification

Integrin Cancer

GRGDSP (TFA) is an integrin inhibitor.
HY-P0290

GRGDSP

4 Publications Verification

Integrin Cancer

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

HY-P3522

REDV	Integrin	Cancer
REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the **integrin alpha 4 beta 1(α4β1)**. REDV can be used for the research of cell adhesion .

HY-P2267

LDV 1 Publications Verification	Integrin	Others
LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells .

HY-P3522A

REDV TFA	Integrin	Cancer
REDV TFA is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV TFA can mediate adhesion to the IIICS region of plasma fibronectin by binding the **integrin alpha 4 beta 1(α4β1)**. REDV TFA can be used for the research of cell adhesion .

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-100563A

Cyclo(RGDyK)

3 Publications Verification

Integrin Cancer

Cyclo(RGDyK) is a potent and selective α_Vβ₃ integrin inhibitor with an IC₅₀ of 20 nM.

HY-P1897

Fibronectin Active Fragment Control	Peptides	Inflammation/Immunology
Fibronectin Active Fragment Control is an active peptide fragment of fibronectin. Fibronectin is a glycoprotein interacting with integrins .

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-P5038

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP)	Integrin	Cancer
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 *integrin* ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .

HY-P0278

RGD 5 Publications Verification	Integrin	Cancer
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to *integrins*.

HY-P10038

mP6 Myr-FEEERA-OH	Integrin	Infection
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα₁₃ with integrin β₃ without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .

HY-P0278A

RGD Trifluoroacetate 5 Publications Verification	Integrin	Cancer
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to *integrins*.

HY-P1188

LDV-FITC	Integrin	Cancer
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC can be used to detect α4β1 integrin affinity .

HY-P0031

Cyclo(RADfK) 1 Publications Verification	Integrin	Others
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

HY-P3530

G-{d-Arg}-GDSP	Peptides	Others
G-{d-Arg}-GDSP is an RGD peptide analogue that binds to the adhesion receptor of integrins and inhibits cellular fibronectin attachment as well as osteoclast resorption .

HY-P4903

RGD-targeted Proapoptotic Peptide	Peptides	Cancer
RGD-targeted Proapoptotic Peptide is a peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis.

HY-P5053

Galacto-RGD

Integrin Cancer

Galacto-RGD is an RGD analogue that can be coupled with the radioactive isotope 18F and used as an integrin α₅β₃ selective tracer .

HY-P5929

VnP-16	Integrin FAK	Inflammation/Immunology
VnP-16 can promote bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation .

HY-P5189A

*His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA*	Endogenous Metabolite Cholinesterase (ChE)	Others
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels .

HY-P5287

cRGDfK-thioacetyl ester	Integrin	Cancer
cRGDfK-thioacetyl ester is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for *integrins*. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging .

HY-P1187

HSDVHK-NH2

Integrin Cancer

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-P5287A

cRGDfK-thioacetyl ester TFA	Integrin	Cancer
cRGDfK-thioacetyl ester TFA is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for *integrins*. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging .

HY-P1187A

HSDVHK-NH2 TFA

Integrin Cancer

HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM) .

HY-125053A

Batifiban TFA	Glycoprotein VI	Cardiovascular Disease
Batifiban TFA, a cyclic peptide, is an antagonist of platelet glycoprotein GPⅡb/Ⅲa and inhibits platelet aggregation. Batifiban blocks the binding of circulating vitronectin to integrin ανβ3 .

HY-P5098

E(c(RGDfK))2	Peptides	Cancer
E(c(RGDfK)) is an αvβ3 integrin-specific binding moiety with tumor targeting properties. Increased uptake of E(c(RGDfK)) in human ovarian cancer OVCAR-3 xenograft tumors may be useful in cancer research .

HY-125053

Batifiban	Integrin	Cardiovascular Disease
Batifiban, a cyclic peptide, is a platelet glycoprotein GPⅡb/Ⅲa antagonist, and inhibits platelet aggregation. Batifiban blocks circulating vitronectin binding to integrin ανβ3, Batifiban can be used for research of acute coronary syndromes .

HY-P5133

Synstatin (92-119) SSTN92-119	Integrin	Cancer
Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) down-regulates **integrin α?β3** and reduces the activation of angiogenic growth factors VEGF and FGF-2 .

HY-P0295

Gly-Arg-Gly-Asp-Ser GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM

HY-P1408

Obtustatin	Integrin	Cancer
Obtustatin is a non-RGD disintegrin of 41 residues. Obtustatin can be isolated from Vipera lebetina obtusa venom. Obtustatin is a potent and selective inhibitor of the adhesion of integrin *α1β1* to collagen IV. Obtustatin inhibits angiogenesis, and can be used for research of cancer .

HY-P0295A

Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA	Integrin	Inflammation/Immunology
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM .

Cat. No.	Product Name	Target	Research Area

HY-P9911A

*Vedolizumab (anti-α4β7-integrin)*	Integrin	Inflammation/Immunology
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease .

HY-P9911

Vedolizumab 1 Publications Verification Anti-human lymphocyte α4β7 integrin, humanized Antibody	Integrin	Inflammation/Immunology Cancer
Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease.

HY-P99291

Etaracizumab LM 609; MEDI 523; Anti-αvβ3 integrin Recombinant Antibody	Integrin	Cancer
Etaracizumab (LM 609) is an α_vβ₃ integrin IgG1 monoclonal antibody. Etaracizumab inhibits angiogenesis and melanoma tumor growth. Etaracizumab can be used to research anticancer .

HY-P990203

*Anti-Mouse LPAM-1/Integrin* α4β7 Antibody (DATK32)**	Inhibitory Antibodies	Others
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse LPAM-1/Integrin α4β7.

HY-P990207

*Anti-Mouse/Human* Integrin β7 Antibody (FIB504)**	Inhibitory Antibodies	Others
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse/human Integrin β7.

HY-P9984

Etrolizumab rhuMAb beta7; RG7413; PRO145223	Integrin	Cancer
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 *integrin* monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with K_i values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) .

HY-P99560

Tadocizumab C4G1; YM-337	Integrin	Cardiovascular Disease
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research .

HY-108831A

Natalizumab (Solution) 1 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab (Solution) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses .

HY-P99184

Abrilumab	Integrin	Infection Inflammation/Immunology Cancer
Abrilumab is a fully human monoclonal antibody directed against *α4β7. Abrilumab selectively binds the α4β7 integrin* heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .

HY-P99333

Volociximab M200; Eos 200-4	Integrin	Cardiovascular Disease Cancer
Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting **integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1** is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

HY-108831

Natalizumab 1 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses .

HY-P99183

Abituzumab EMD 525797; DI17E6	Integrin	Cancer
Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W008859

Tetrac 1 Publications Verification Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Integrin Endogenous Metabolite
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-P3160

Fibronectin 1 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Integrin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-N2587

Irigenin	Flavonoids Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Cancer	Integrin Apoptosis
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking *α9β1* and *α4β1* integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-122552

Chrysotobibenzyl	Structural Classification Natural Products Orchidaceae Source classification Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Integrin
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) .

Species:	Human (40) Rhesus Macaque (3) Mouse (14) Cynomolgus (2)
Tag:	His (55) SUMO (1) Avi (14) Myc (1) Flag (7) Fc (2)
Source:	HEK293 (54) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P700768

	*ITGB6 Protein, Human* (HEK293, His)** integrin beta-6; integrin beta 6; beta 6; integrin β-6; integrin β 6; β 6	Human	HEK293
	The ITGB6 protein forms integrin alpha-V:beta-6 (ITGAV:ITGB6), which acts as a receptor for fibronectin, chemokines, and fibrillin-1. It recognizes the RGD sequence in the ligand and promotes cancer cell invasion through clathrin-mediated endocytosis. ITGB6 Protein, Human (HEK293, His) is the recombinant human-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of ITGB6 Protein, Human (HEK293, His) is 686 a.a., with molecular weight of 80-115 kDa.

HY-P700769

	*ITGB6 Protein, Mouse (HEK293, His)* integrin beta-6; ITGB6; integrin β-6	Mouse	HEK293
	ITGB6 is a multifunctional receptor that recognizes RGD sequences in ligands such as fibronectin, chemoattractants, and fibrillin-1 (FBN1) and plays a key role in mediating RGD-dependent cell adhesion. . Its key functions include the release of transforming growth factor beta-1 (TGF-beta-1) from latency-associated peptide (LAP), thereby activating TGF-beta-1. ITGB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of ITGB6 Protein, Mouse (HEK293, His) is 685 a.a., with molecular weight of 80-115 kDa.

HY-P73868

	Integrin alpha V beta 3 Protein, Human (HEK293, His, solution) CD51; integrin alpha V beta 3; integrin alpha-V; MSK8	Human	HEK293
	Integrin α V beta 3 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 3 Protein, Human (HEK293, His, solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, His, solution), has molecular weight of ~193.32 kDa.

HY-P72535

	Integrin alpha V beta 8 Protein, Human (HEK293, His) integrin alpha V beta 8; ITGAV&ITGB8; integrin alpha V beta 8 Heterodimer; integrin alpha V & beta 8	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 8 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein, expressed by HEK293, with C-6*His labeled tag. Integrin alpha V beta 8 Protein, Human (HEK293, His), has molecular weight of 125-160 & 80-100 kDa, respectively.

HY-P77721A

	Integrin alpha V beta 6 Protein, Human (HEK293, His) CD51; integrin alpha V beta 6; integrin subunit alpha V; ITGAV; MSK8; VNRA; VTNR	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 6 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 6 Protein, Human (HEK293, His), has molecular weight of ~130 & 95 KDa, respectively.

HY-P73866

	Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His) CD51; integrin alpha V beta 6; integrin subunit alpha V; ITGAV; MSK8; VNRA; VTNR	Mouse	HEK293
	Integrin alpha V beta 6 protein, a key member of the integrin superfamily, crucially engages in cell adhesion and signaling through heterodimer formation with beta chains, including beta 1, beta 3, beta 6, and beta 8. As the Vitronectin receptor, the alpha V beta 3 heterodimer interacts with multiple extracellular matrix proteins, mediating cell adhesion and influencing cell migration. Its deficiency in mice leads to vascular morphogenesis defects in the brain and early post-natal mortality. Integrin alpha V beta 6 is widely expressed, notably in tissues like adult placenta and ovary. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His), has molecular weight of ~190.4 kDa.

HY-P73867

	Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His) CD51; integrin alpha V beta 6; integrin subunit alpha V; ITGAV; MSK8; VNRA; VTNR	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His), has molecular weight of ~190.4 kDa.

HY-P700763

	Integrin alpha V beta 8 Protein, Mouse (HEK293, His) αVβ8; integrin alpha V beta 8; ITGAV&ITGB8; integrin alpha V β 8	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 8 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 8 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 8 Protein, Mouse (HEK293, His), has molecular weight of 80-140 kDa.

HY-P700762

	Integrin alpha V beta 6 Protein, Human (Biotinylated, HEK293, His-Avi) αVβ6; integrin alpha V beta 6; ITGAV&ITGB6; integrin alpha V β 6	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 6 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 6 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 90-150 kDa.

HY-P700767

	Integrin alpha V beta 8 Protein, Human (Biotinylated, HEK293, His-Avi) αVβ8; integrin alpha V beta 8; TGAV&ITGB8; integrin alpha V β 8	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 8 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 8 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 85-145 kDa.

HY-P77723

	Integrin alpha V beta 6 Protein, Mouse (HEK293, His) ITGAV&ITGB6; integrin alpha V beta 6	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 6 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, His), has molecular weight of 90-140 kDa.

HY-P77721

	Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi) integrin alpha V beta 6; ITGAV&ITGB6	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Avi labeled tag. Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi), has molecular weight of 90-150 kDa.

HY-P77722

	Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi) integrin alpha V beta 8; TGAV&ITGB8	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi), has molecular weight of 90-150 kDa.

HY-P77724

	Integrin alpha V beta 6 Protein, Rhesus Macaque (HEK293, His) ITGAV&ITGB6; integrin alpha V beta 6	Rhesus Macaque	HEK293
	Integrin alpha V beta 6 Protein, part of the integrin alpha chain family, is featured. Integrin alpha V beta 6 Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 6 Protein, Rhesus Macaque (HEK293, His), has molecular weight of 90-140 kDa.

HY-P77725

	Integrin alpha V beta 8 Protein, Rhesus Macaque (HEK293, His) integrin alpha V beta 8; ITGAV&ITGB8	Rhesus Macaque	HEK293
	Integrin alpha V beta 6 Protein, part of the integrin alpha chain family, is featured. Integrin alpha V beta 8 Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived Integrin alpha V beta 8 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 8 Protein, Rhesus Macaque (HEK293, His), has molecular weight of 90-140 kDa.

HY-P700760

	Integrin alpha V beta 3 Protein, Mouse (HEK293, hFc) αVβ3; integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; integrin alpha V β 3; β3	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 3 Protein, Mouse (HEK293, hFc) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-hFc labeled tag. Integrin alpha V beta 3 Protein, Mouse (HEK293, hFc), has molecular weight of 110-135 kDa & 50-60 kDa, respectively.

HY-P700761

	Integrin alpha V beta 3 Protein, Mouse (HEK293, His) αVβ3; integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; integrin alpha V β 3; β3	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 3 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 3 Protein, Mouse (HEK293, His), has molecular weight of 90-130 kDa.

HY-P701063

	Integrin alpha V beta 3 Protein, Cynomolgus (HEK293, His) αVβ3; integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; integrin alpha V β 3; β3	Cynomolgus	HEK293
	Integrin alpha V beta 3 Protein, part of the integrin alpha chain family, is highlighted. Integrin alpha V beta 3 Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 3 Protein, Cynomolgus (HEK293, His), has molecular weight of 95-140 kDa.

HY-P73872

	Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His) CD49e; FNRA; integrin alpha 5 beta 1; integrin alpha-F; VLA-5; ITGB1; CD29	Human	HEK293
	ITGA5, a versatile receptor, interacts with diverse ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, Human metapneumovirus, and soluble CD40LG. Recognizing the R-G-D sequence, ITGA5 mediates cell adhesion through distinct binding sites. Notably, it binds PLA2G2A at a separate site, inducing conformational changes enhancing ligand binding. ITGA5's role in IL1B signaling, microbial infection, and CD40/CD40LG signaling highlights its multifunctionality in cellular processes and signaling pathways. Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein, expressed by HEK293, with C-Flag, C-10*His labeled tag. Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His), has molecular weight of ~101.35 kDa.

HY-P700765

	Integrin alpha V beta 3 Protein, Human (Biotinylated, HEK293, His-Avi) αVβ3; integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; integrin alpha V β 3; β3	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 3 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 3 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 90-145 kDa.

HY-P700766

	Integrin alpha V beta 5 Protein, Human (Biotinylated, HEK293, His-Avi) αVβ5; integrin alpha V beta 5; beta5; alphaV; ITGAV&ITGB5; integrin alpha V β 5; β5	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 5 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 5 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 5 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 85-140 kDa.

HY-P701015

	Integrin alpha V beta 3 Protein, Mouse (Biotinylated, HEK293, His-Avi) αVβ3; integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3; integrin alpha V β 3; β3	Mouse	HEK293
	Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 3 Protein, Mouse (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha V beta 3 Protein, Mouse (Biotinylated, HEK293, His-Avi), has molecular weight of 90-130 kDa.

HY-P72533

	*ITGA5 Protein, Human* (HEK293, His)** integrin alpha-5; Fibronectin Receptor Subunit alpha; integrin alpha-F; VLA-5; CD49e; ITGA5; FNRA	Human	HEK293
	ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, human metapneumovirus, and soluble CD40LG. ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites. ITGA5 Protein, Human (HEK293, His) is the recombinant human-derived ITGA5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ITGA5 Protein, Human (HEK293, His) is 954 a.a., with molecular weight of ~130 kDa.

HY-P73865

	Integrin alpha V beta 8 Protein, Human (HEK293, His, solution) integrin alpha V beta 8; CD51; ITGAV; ITGB8	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 8 Protein, Human (HEK293, His, solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 8 Protein, Human (HEK293, His, solution), has molecular weight of ~187.95 kDa.

HY-P73862

	Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) integrin beta-1; CD29; ITGB1; FNRB; MDF2; MSK12	Human	HEK293
	Integrin beta-1/CD29 forms distinct heterodimers that act as multifunctional receptors for extracellular matrix proteins. It recognizes collagen, fibronectin, fibrinogen and laminin and plays a key role in cell functions such as migration, adhesion and angiogenesis. Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) is the recombinant human-derived Integrin beta-1/CD29 protein, expressed by HEK293 , with C-8*His labeled tag. The total length of Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) is 708 a.a., with molecular weight of 90-145 kDa.

HY-P73863

	Integrin alpha X beta 2 Protein, Human (HEK293, His) integrin alpha X beta 2; CD11c; ITGAX; CD18; ITGB2	Human	HEK293
	Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha X beta 2 Protein, Human (HEK293, His), has molecular weight of 130-150 kDa (ITGAX) & 85-96 kDa (ITGB2), respectively.

HY-P77719

	Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi) integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3	Human	HEK293
	Integrin alpha V beta 5 Proteinas, specifically the alpha-V (ITGAV) subunit, is a versatile receptor for ligands like vitronectin, fibronectin, and others, recognizing the R-G-D sequence. ITGAV:ITGB3 binds fractalkine, acting as a coreceptor in CX3CR1-dependent signaling. It forms crucial interactions with NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, CD40LG, contributing to diverse pathways. Notably, ITGAV:ITGB3 or ITGAV:ITGB6 is a receptor for TGF-beta-1, mediating its release from LAP and playing a crucial role in TGF-beta-1 activation. Additionally, ITGAV:ITGB5 functions as an Adenovirus type C receptor during microbial infection. Integrin alpha V beta 5's integrative nature underscores its pivotal role in diverse cellular responses and signaling cascades. Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293, with C-His, C-Avi labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi), has molecular weight of 85-140 kDa.

HY-P77720

	Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi) integrin alpha V beta 5; beta5; alphaV; ITGAV&ITGB5	Human	HEK293
	Integrin α V beta 5 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi), has molecular weight of 85-160 kDa.

HY-P73864

	Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His) integrin alpha X beta 2; CD11c; ITGAX; CD18; ITGB2	Human	HEK293
	Integrin alpha-X/beta-2, a receptor for fibrinogen, crucially recognizes the G-P-R sequence. It plays a pivotal role in inflammatory responses, especially in monocyte adhesion and chemotaxis. Structurally, forming a heterodimer, the alpha-X subunit associates with the beta-2 subunit. This receptor's fibrinogen recognition underscores its significance in immune responses, emphasizing its role in regulating monocyte functions and cell migration during inflammation. Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His), has molecular weight of ~95 & 130 kDa, respectively.

HY-P700764

Integrin alpha 6 beta 1 Protein, Human (HEK293, His-Avi)

α6β1; integrin alpha 6 beta 1; ITGA6&ITGB1; integrin alpha 6 β 1
Human HEK293
HY-P702621

Integrin alpha 6 beta 1 Protein, Human (Biotinylated, HEK293, His, Avi)

α6β1; integrin alpha 6 beta 1; ITGA6&ITGB1; integrin alpha 6 β 1
Human HEK293

HY-P71448

	*ITGBL1 Protein, Human* (Myc, His)** ITGBL1; OSCP; TIED; integrin beta-like protein 1; Osteoblast-specific cysteine-rich protein; Ten integrin EGF-like repeat domain-containing protein	Human	E. coli
	Integrin beta-like protein 1 (ITGBL1) is a beta integrin-related protein that is a member of the EGF-like protein family, containing integrin-like cysteine-rich repeats and may has integrin binding activity. ITGBL1 might be involved in cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. ITGBL1 Protein, Human (Myc, His) is the recombinant human-derived ITGBL1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of ITGBL1 Protein, Human (Myc, His) is 471 a.a., with molecular weight of ~67 kDa.

HY-P73869A

	Integrin alpha 8 beta 1 Protein, Human (HEK293, His) integrin alpha 8 beta 1; ITGA8; ITGB1	Human	HEK293
	Integrin alpha-8/beta-1 orchestrates mesenchymal cell recruitment during kidney organogenesis, recognizing the R-G-D sequence in ligands like TNC, FN1, SPP1, TGFB1, TGFB3, and VTN. Its role in diverse cellular interactions, crucial for organ formation, includes NPNT as a functional ligand in kidney genesis. As a neuronal receptor for TNC, it modulates neurite outgrowth in sensory and motor neurons. Structurally, Integrin alpha-8/beta-1 forms a heterodimer with the alpha-8 subunit associating with the beta-1 subunit, emphasizing its integral role in cell-matrix and cell-cell interactions during organ development and neural processes. Integrin alpha 8 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 8 beta 1 Protein, Human (HEK293, His), has molecular weight of 120-140 kDa & 100-120 kDa, respectively.

HY-P700755

	Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi) integrin alpha 5 beta 1; VLA-5; ITGA5&ITGB1; integrin alpha 5 β 1; α5β1	Human	HEK293
	ITGA5, a versatile receptor, interacts with diverse ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, Human metapneumovirus, and soluble CD40LG. Recognizing the R-G-D sequence, ITGA5 mediates cell adhesion through distinct binding sites. Notably, it binds PLA2G2A at a separate site, inducing conformational changes enhancing ligand binding. ITGA5's role in IL1B signaling, microbial infection, and CD40/CD40LG signaling highlights its multifunctionality in cellular processes and signaling pathways. Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 110-140 kDa.

HY-P73869

	Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His) integrin alpha 8 beta 1; ITGA8; ITGB1	Human	HEK293
	Integrin alpha-8/beta-1 orchestrates mesenchymal cell recruitment during kidney organogenesis, recognizing the R-G-D sequence in ligands like TNC, FN1, SPP1, TGFB1, TGFB3, and VTN. Its role in diverse cellular interactions, crucial for organ formation, includes NPNT as a functional ligand in kidney genesis. As a neuronal receptor for TNC, it modulates neurite outgrowth in sensory and motor neurons. Structurally, Integrin alpha-8/beta-1 forms a heterodimer with the alpha-8 subunit associating with the beta-1 subunit, emphasizing its integral role in cell-matrix and cell-cell interactions during organ development and neural processes. Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein, expressed by HEK293, with C-10*His, C-Flag labeled tag. Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His), has molecular weight of ~85-140 kDa.

HY-P73870

Integrin alpha 6 beta 4 Protein, Human (HEK293, Flag-His)

integrin alpha 6 beta 4; ITGA6; ITGB4
Human HEK293

HY-P73868A

	Integrin alpha V beta 3 Protein, Human (HEK293, C-His)	Human	HEK293
	Integrin α V beta 3 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 3 Protein, Human (HEK293, C-His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293 , with C-10*His labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, C-His), has molecular weight of ~90.31 & 110-150 kDa, respectively.

HY-P72241

	*IBSP Protein, Human* (His-SUMO)** BNSP; Bone sialoprotein 2; Bone sialoprotein II; BSP; BSP II; BSPII; Cell binding sialoprotein; Cell-binding sialoprotein; IBSP; integrin binding sialoprotein; integrin-binding sialoprotein; SIAL_human; SPII	Human	E. coli
	The IBSP protein has a strong affinity for hydroxyapatite and plays a crucial role in mineralized matrix formation, indicating its overall nature in this regard. Its tight binding suggests an important role in cell-matrix interactions, particularly in promoting RGD-dependent cell attachment. IBSP Protein, Human (His-SUMO) is the recombinant human-derived IBSP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of IBSP Protein, Human (His-SUMO) is 153 a.a., with molecular weight of ~32.4 kDa.

HY-P77718

	Integrin alpha 5 beta 1 Protein, Human (HEK293, His-Avi) integrin alpha 5 beta 1; VLA-5; ITGA5&ITGB1	Human	HEK293
	ITGA5, a versatile receptor, interacts with diverse ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, Human metapneumovirus, and soluble CD40LG. Recognizing the R-G-D sequence, ITGA5 mediates cell adhesion through distinct binding sites. Notably, it binds PLA2G2A at a separate site, inducing conformational changes enhancing ligand binding. ITGA5's role in IL1B signaling, microbial infection, and CD40/CD40LG signaling highlights its multifunctionality in cellular processes and signaling pathways. Integrin alpha 5 beta 1 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha 5 beta 1 Protein, Human (HEK293, His-Avi), has molecular weight of 100-140 kDa.

HY-P73871

Integrin alpha 6 beta 1 Protein, Human (HEK293, Flag-His)

CD49f; integrin alpha 6 beta 1; ITGA6B; VLA-6
Human HEK293

HY-P700750

	Integrin alpha 10 beta 1 Protein, Human (HEK293, His) integrin alpha 10 beta 1; ITGA10&ITGB1; α10β1	Human	HEK293
	Integrin alpha-10/beta-1, a collagen-specific receptor, crucially mediates cell interactions with the extracellular matrix. Comprising alpha-10 and beta-1 subunits, their stable association forms a heterodimeric complex. This interaction facilitates adhesion and signaling events, influencing essential aspects of cell behavior and tissue organization. Understanding Integrin alpha-10/beta-1's nuances provides insights into its significance in mediating cell-matrix interactions, offering implications in physiological and pathological contexts. Integrin alpha 10 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 10 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 10 beta 1 Protein, Human (HEK293, His), has molecular weight of 140-160 kDa (ITGA10) & 100-130 kDa (ITGB), respectively.

HY-P700751

	Integrin alpha 10 beta 1 Protein, Mouse (HEK293, His) integrin alpha 10 beta 1; ITGA10&ITGB1; α10β1	Mouse	HEK293
	Integrin alpha 10 beta 1 Protein, within the integrin alpha chain family, is emphasized. Integrin alpha 10 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 10 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 10 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 140-170 kDa (ITGA10) & 100-130 kDa (ITGB), respectively.

HY-P702626

Integrin alpha V beta 1 Protein, Human (HEK293, His, Avi)

ITGAV:ITGB1
Human HEK293

HY-P70257

	Integrin beta-1/CD29 Protein, Human (HEK293, His) rHuintegrin beta-1/ITGB1, his; integrin beta-1; Fibronectin Receptor Subunit beta; VLA-4 Subunit beta; CD29; ITGB1; FNRB; MDF2; MSK12	Human	HEK293
	Integrin beta-1/CD29 forms distinct heterodimers that act as multifunctional receptors for extracellular matrix proteins. It recognizes collagen, fibronectin, fibrinogen and laminin and plays a key role in cell functions such as migration, adhesion and angiogenesis. Integrin beta-1/CD29 Protein, Human (708a.a, HEK293, His) is the recombinant human-derived Integrin beta-1/CD29 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Integrin beta-1/CD29 Protein, Human (708a.a, HEK293, His) is 708 a.a., with molecular weight of 100-130 kDa.

HY-P700756

	Integrin alpha A1 beta 1 Protein, Human (HEK293, His) integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; integrin alpha A1 β 1; alpha A1 β 1; β 1	Human	HEK293
	ITGA1 Protein, a cell surface receptor, plays a crucial role in cell adhesion, migration, and tissue development. Dysregulation of ITGA1 Protein has been linked to various diseases, including cancer and fibrosis. Targeting ITGA1 Protein may provide potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting tumor growth, and preventing tissue fibrosis. Integrin alpha A1 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha A1 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Human (HEK293, His), has molecular weight of 160-200 kDa.

HY-P700757

	Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His) integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; integrin alpha A1 β 1; alpha A1 β 1; β 1	Mouse	HEK293
	Integrin alpha-1/beta-1, a receptor for laminin and collagen, recognizes the proline-hydroxylated sequence G-F-P-G-E-R within collagen. This integral protein negatively regulates EGF-stimulated cell growth and forms a heterodimeric complex with beta-1, interacting with the small GTPase RAB21. Through its cytoplasmic domain, Integrin alpha-1/beta-1 engages with PTPN2, activating phosphatase activity towards EGFR, exerting a negative regulatory influence on EGF signaling, highlighting its multifaceted role in cellular responses. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha A1 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 140-200 kDa (ITGA1) & 100-115 kDa (ITGB1), respectively.

HY-P7674

	*BSP2 Protein, Mouse (HEK293, His)* rMuBSP2, his; IBSP; integrin binding sialoprotein; Bone sialoprotein 2	Mouse	HEK293
	BSP2 Protein, Mouse (HEK293, His) is a recombinant mouse bone sialoprotein 2 produced in HEK293 cells. Bone Sialoprotein 2, one of the major bone matrix proteins, with its previously known role in osseous tissue degradation, has been recently proven to play a role in the nucleation of hydroxyl apatite during osseous tissue mineralization.

HY-P700758

	Integrin alpha L beta 2 Protein, Mouse (HEK293, His) αLβ2; ITGAL&ITGB2; ITGAL; ITGB2	Mouse	HEK293
	Integrin alpha L beta 2 Protein, a receptor for ICAM1, ICAM2, ICAM3, ICAM4, and F11R, participates in immune phenomena, including leukocyte-endothelial cell interaction, cytotoxic T-cell killing, and antibody-dependent killing. It contributes to natural killer cell cytotoxicity and leukocyte adhesion and transmigration. Essential for common lymphoid progenitor cell generation, indicating a role in lymphopoiesis. In association with ICAM3, it contributes to apoptotic neutrophil phagocytosis by macrophages. Interacts with THBD. Integrin alpha L beta 2 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha L beta 2 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha L beta 2 Protein, Mouse (HEK293, His), has molecular weight of 160-180 kDa (ITGAL) & 90-105 kDa (ITGB2), respectively.

HY-P75675

	*CIB2 Protein, Human* (His)** Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP2	Human	E. coli
	CIB2 protein: Calcium and integrin-binding protein involved in intracellular calcium regulation, auditory hair cell mechanotransduction, and maintenance of stereocilia bundle morphology. CIB2 Protein, Human (His) is the recombinant human-derived CIB2 protein, expressed by E. coli , with N-His labeled tag. The total length of CIB2 Protein, Human (His) is 187 a.a., with molecular weight of ~26 kDa.

HY-P75675A

CIB2 Protein, Human (N-His)

Calcium and integrin-binding family member 2; Kinase-interacting protein 2; KIP2
Human E. coli

Cat. No.	Product Name	Chemical Structure

HY-113439S

12-HETE-d8
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].

Cat. No.	Product Name	Application	Reactivity

HY-P80417

Integrin alpha V Antibody	WB, ICC, FC	Human
Integrin alpha V Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 116 kDa, targeting to Integrin alpha V. It can be used for WB,ICC,FC assays with tag free, in the background of Human.

HY-P83363

Integrin beta 5 Antibody (YA3108)

integrin beta-5
WB Human, Hamster, Rat
HY-P83306

Integrin alpha E Antibody (YA3051)

integrin alpha-E; HML-1 antigen; integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD103; ITGAE
IHC-P Human
HY-P83377

Integrin beta 6 Antibody (YA3122)

AI1H; integrin beta-6
WB, IP Human, Mouse, Rat
HY-P81498

CD103 Antibody (YA1243)

integrin alpha-E; HML-1 antigen; integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD103; ITGAE; integrin alpha E
IHC-P Human

HY-P80416

Integrin alpha 5 Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
Integrin alpha 5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 115 kDa, targeting to Integrin alpha 5. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P80418

Integrin beta 1 Antibody	WB, IHC-P, FC	Human, Mouse
Integrin beta 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 88 kDa, targeting to Integrin beta 1. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80419

Integrin beta 3 Antibody	WB, IHC-P, ICC/IF	Human, Mouse
Integrin beta 3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to Integrin beta 3. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P80969

BNSP Antibody integrin binding sialoprotein; BSP; BNSP; SP-II; BSP-II；IBSP; Bone sialoprotein II; Cell binding sialoprotein; integrin binding sialoprotein; SIAL_human; Bone sialoprotein 2; Cell-binding sialoprotein; integrin-binding sialoprotein.	WB, IHC-P, IHC-F, IF, ELISA	Mouse, Rat (predicted: Human)
IBSP Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 35 kDa, targeting to IBSP. It can be used for WB, IHC-P assays with tag free, in the background of Human, Mouse.

HY-P83456

Integrin alpha 4 Antibody (YA3201)

ITGA4; CD49D; integrin alpha-4; CD49 antigen-like family member D; integrin alpha-IV; VLA-4 subunit alpha; CD49d
WB Human
HY-P82094

Integrin alpha IIb Antibody (YA1839)

ITGA2B; GP2B; ITGAB; integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41
WB Human, Rat
HY-P83366

Integrin Linked ILK Antibody (YA3111)

ILK; ILK1; ILK2; integrin-linked protein kinase; 59 kDa serine/threonine-protein kinase; ILK-1; ILK-2; p59ILK
WB, IP Human, Mouse, Rat
HY-P83535

Integrin beta 4 Antibody (YA3280)

CD104; gp150; integrin beta 4 subunit; ITG B4; ITGB 4; Itgb4
WB, IHC-P Human, Mouse

HY-P81176

CD11c Antibody integrin alpha-X; integrin alpha-X precursor; ITGAX; SLEB6; CD11C (p150) alpha polypeptide; complement receptor 4; integrin aX; CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; leukocyte adhesion glycoprotein p150,95 alpha chain; ITAX_human.	ELISA; Flow-Cyt; IF	Human, Rat(predicted: Mouse, Dog)
CD11c Antibody is an unconjugated, approximately 126 kDa, rabbit-derived, anti-CD11c polyclonal antibody. CD11c Antibody can be used for: ELISA, Flow-Cyt, IF expriments in human, rat, and predicted: mouse, dog background without labeling.

HY-P81915

Integrin alpha 9 Antibody (YA1660)

alpha RLC; ITGA4L; ITGA9; RLC
WB, IHC-P Human, Mouse, Rat

HY-P83362

Integrin alpha 2 Antibody (YA3107) ITGA2; CD49B; integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

HY-P82653

Integrin alpha L Antibody (YA2398) ITGAL; CD11A; integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a	WB, IHC-F, IHC-P, ICC/IF, IP	Human

HY-P83614

CD209 Antibody (YA3359)

CD209; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD209
WB Human
HY-P83275

Integrin alpha 6 Antibody (YA3020)

ITGA6; CD49 antigen-like family member F; VLA-6; CD49f
WB, IHC-P Human, Mouse, Rat

HY-P80795

Phospho-CD18 (Ser745) Antibody ITGB2; CD18; MFI7; integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18	WB, IP	Human, Mouse, Rat
Phospho-CD18 (Ser745) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Phospho-CD18 (Ser745). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

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