Neuropilin-1 Protein, Human (644a.a, HEK293, His)

Neuropilin-1 (NRP1) is one of two neuropilins which acts as a cell-surface receptor which is involved in the development of the cardiovascular system, angiogenesis, the formation of certain neuronal circuits, organogenesis outside the nervous system, cellular internalization and vascular leakage as well as mediates the chemorepulsant activity of semaphorins. NRP1 also binds many ligands and various types of co-receptors to affect cell survival, migration, and attraction. Neuropilin-1 Protein, Human (644a.a, HEK293, His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (644a.a, HEK293, His) is 623 a.a., with molecular weight of ~90 kDa.

Neuropilin-1 (NRP1) is one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. NRP1 contains a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains, it also contains a short membrane-spanning domain and a small cytoplasmic domain.
NRP1 acts as a cell-surface receptor which is involved in the development of the cardiovascular system, angiogenesis, the formation of certain neuronal circuits and organogenesis outside the nervous system as well as mediates the chemorepulsant activity of semaphorins. NRP1 also recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage.
NRP1 binds many ligands and various types of co-receptors to affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by NRP1 are vascular endothelial growth factor (VEGF) and semaphorin family members.
NRP1 also acts as a host factor for human coronavirus SARS-CoV-2 infection as NRP1 recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection^[1][2][3][4].

Human

HEK293

C-His

NP_001019799.1 (F22-K644)

8829  [NCBI]

FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK

Approximately 90 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.