1. Recombinant Proteins
  2. Recombinant Human Insulin-like Growth Factor-Binding Protein 5

Recombinant Human Insulin-like Growth Factor-Binding Protein 5

Cat. No.: HY-P7021
Handling Instructions

Recombinant Human Insulin-like Growth Factor-Binding Protein 5 is a unique insulin-like growth factor-binding protein, modulates the actions of secreted insulin-like growth factors, and stimulates osteoblast proliferation.

For research use only. We do not sell to patients.

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Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $180 In-stock
Estimated Time of Arrival: December 31
50 μg $480 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuIGF-BP5; IBP-5
Species

Human

Source

CHO

Accession

P24593

Gene ID

3488

Molecular Weight

Approximately 28.3 kDa

AA Sequence

LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLP

Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against 20 mM PB, 150mM NaCl, pH 6.2.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

Reconstituted the lyophilized Human Insulin-like Growth Factor-Binding Protein 5 (rHuIGF-BP5) in ddH2O at 100 μg/mL.

Storage & Stability

Lyophilized recombinant Human Insulin-like Growth Factor-Binding Protein 5 (rHuIGF-BP5) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Human Insulin-like Growth Factor-Binding Protein 5 (rhIGFBP-5) is a unique and most abundant IGFBP stored in bone, having a high specific binding affinity for hydroxyapatite and extracellular matrix proteins, therefore fixing it and its bound IGFs within bone. rhIGFBP-5 consistently stimulates osteoblast cell proliferation in vitro, thus increasing the number of osteoblasts[1].

Documentation
References
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Product Name:
Recombinant Human Insulin-like Growth Factor-Binding Protein 5
Cat. No.:
HY-P7021
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