1. Recombinant Proteins
  2. Recombinant Human Interleukin-17

Recombinant Human Interleukin-17

Cat. No.: HY-P7036
Handling Instructions

Recombinant human IL-17, produced in E. coli, is a proinflammatory cytokine

For research use only. We do not sell to patients.

Protein Expression Service

Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $140 In-stock
Estimated Time of Arrival: December 31
50 μg $300 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Species

Human

Source

E. coli

Accession

Q16552

Gene ID

3605

Molecular Weight

Approximately 15.3 kD

AA Sequence

IVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

Biological Activity
The ED50 is <10 ng/mL.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against 20 mM PB, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

Reconstitute the lyophilized recombinant Human Interleukin-17 (rHuIL-17) to 100 µg/mL using ddH2O.

Storage & Stability

Lyophilized recombinant Human Interleukin-17 (rHuIL-17) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

The interleukin-17 (IL-17) cytokines, IL-17A to IL-17F, are emerging as critical players in host defence responses and inflammatory diseases. The interleukin-17 (IL-17) cytokines are emerging as key players in immune responses. The first member to be identified, IL-17A, is originally cloned as cytotoxic T-lymphocyte antigen-8, a gene sharing homology with the HSV13 gene from herpesvirus Saimiri. The other members, IL-17B to IL-17F are subsequently identified based on their homology to IL-17A. These proteins are highly conserved at the C terminus, and contain five spatially conserved cysteine residues that mediate dimerization. Members of the IL-17 receptor family, IL-17RA to IL-17RE, mediate the biological functions of these cytokines. Accumulating evidence indicates that these interactions induce pro-inflammatory programmes[1].

Documentation
References
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Product Name:
Recombinant Human Interleukin-17
Cat. No.:
HY-P7036
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