1. Recombinant Proteins
  2. Recombinant Mouse Activin Receptor-like Kinase 1, C-Fc (HEK293-expressed)

Recombinant Mouse Activin Receptor-like Kinase 1, C-Fc (HEK293-expressed)

Cat. No.: HY-P7481
Handling Instructions

Recombinant Mouse Activin Receptor-like Kinase 1, C-Fc (HEK293-expressed) mediates signaling via the transforming growth factor beta-1 (TGFβ1), a pro-fibrogenic cytokine[1].

For research use only. We do not sell to patients.

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10 μg $60 Ask For Quote & Lead Time
50 μg $140 Ask For Quote & Lead Time

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  • Technical Parameters

  • Properties

  • Description

Synonyms
rMuActivin Receptor-like Kinase 1, C-Fc; ALK-1; ACVRL1; Activin Receptor-like Kinase 1
Species

Mouse

Source

HEK 293

Accession

Q61288

Gene ID

11482

Molecular Weight

55-60 kDa

AA Sequence

DLAKPSKLVN CTCESPHCKR PFCQGSWCTV VLVREQGRHP QVYRGCGSLN QELCLGRPTE FLNHHCCYRS FCNHNVSLML EATQTPSEEP EVDAHLP

Biological Activity
Data is not available.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

Reconstitute the lyophilized recombinant Mouse Activin Receptor-like Kinase 1, C-Fc (HEK293-expressed) (rMuActivin Receptor-like Kinase 1, C-Fc) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability

Lyophilized recombinant Mouse Activin Receptor-like Kinase 1, C-Fc (HEK293-expressed) (rMuActivin Receptor-like Kinase 1, C-Fc) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

ALK1 is a cell surface serine-threonine kinase that serves an established role in maintaining vascular homeostasis. Loss of function mutations in human ALK1 result in hereditary hemorrhagic telangiectasia type 2 (HHT2), characterized by the presence of arteriovenous malformations in the brain, lungs, visceral organs, and skins. In mice, homozygous deletion of Alk1 results in embryonic lethality due to severe defects in cardiovascular development. Global inducible knockout of Alk1 in adult mice results in lethality associated with the formation of arteriovenous malformations in the gastrointestinal tract and subsequent development of high output HF. For this reason, several studies have employed the Alk1 heterozygous mouse model to study the post-natal effects of ALK1 deficiency[1].

Documentation
References
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Recombinant Mouse Activin Receptor-like Kinase 1, C-Fc (HEK293-expressed)
Cat. No.:
HY-P7481
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